@stephanhacker2.bsky.socialExciting talk by Yoav Shamir from the group of Nir London at #CovModDrugDisvov!
He talked about cofolding in Alphafold3 to identify #CovalentInhibitors with novel structures for BTK.
#DrugDiscovery #Kinase #ChemSky #ChemBio #Science
@britpharmsoc.bsky.social
@quartzmedia.bsky.socialICYMI: An AI lab that never stops learning just entered drug discovery #ArtificialIntelligence #DrugDiscovery
@stephanhacker2.bsky.socialInteresting talk by Chloe Oxford from GSK at #CovModDrugDiscov.
She talked about a MALDI-TOF-MS-based assay to characterize the binding of #CovalentInhibitors to challenging proteins with resolution of the binding site.
@stephanhacker2.bsky.socialInteresting talk by Federica Raguseo at #CovModDrugDiscov.
She talked about a phenotype-first approach to covalent drug discovery on the example of TYMS.
www.biorxiv.org/content/10.6...
#CovalentInhibitor #DrugDiscovery #ChemSky #ChemBio #Science
@britpharmsoc.bsky.social
@stephanhacker2.bsky.socialExciting talk by @meganwright.bsky.social at #CovModDrugDiscov.
She talked about new chemical methods to make libraries of covalent compounds and using them in MS-based and phenotypic screens.
#DrugDiscovery #ChemSky #ChemBio #Science
@britpharmsoc.bsky.social
@fiosgenomics.bsky.socialDiscover how data landscaping and #datamining can further your research while eliminating the costs associated with data-generation!
Find out more about our data mining service:⬇️
https://www.fiosgenomics.com/service/data-mining-landscaping/
@bizbln.bsky.socialAlphabets AI Lab raises forty billion to speed drug discovery with ML partnering Eli Lilly and Novartis. Big hype big hope! #AI #DrugDiscovery #Biotech #DeepMind #Funding #Innovation
@medinadiscovery.bsky.socialIf you are attending, find Carmen at poster 276 on 14 and 15 October.
#ELRIGDD26 #ELRIGDD26 #DrugDiscovery #TripleNegativeBreastCancer #NaturalProducts #3DCellModels #MachineLearning
@stephanhacker2.bsky.socialInteresting talk by Darrin McKenzie at #CovModDrugDiscov.
He talked about, how they set up an automated platform to study protein expression levels and cysteine engagement in living cells.
#CovalentInhibitor #DrugDiscovery #ChemBio #ChemSky #ChemicalProteomics #Science
@stephanhacker2.bsky.socialAlways great to see the amazing work by Patrick Zanon in our group highlighted in the talk of others.
www.nature.com/articles/s41...
#CovalentInhibitor #DrugDiscovery #ChemSky #ChemBio #Science #ChemPro #ProteoProbes
@britpharmsoc.bsky.social
@stephanhacker2.bsky.socialThe 2nd day of #CovModDrugDiscov gets on the way with an inspiring talk by Steven Gygi.
He talked about the power of TMT technologies for multiplexing to arrive at high-throughput residue-specific chemoproteomics.
#CovalentInhibitor #DrugDiscovery #ChemSky #ChemBio #ChemicalProteomics #Science
@informaq.bsky.socialNovel QAOA pipeline with constraint-preserving ansatz and W-state initialization optimizes protein sidechain packing, reducing two-qubit gate scaling from O(MN²) to O(MN). Improves upon AlphaFold2 baseline, especially in moderate-confidence regions.
@andrei8iordache.bsky.socialPossible solution: If the governments buys up volumes of new molecules,
commercial and investor interest eventually sync up. Happened before. With penicillin. #AMR #AntibioticResistance #PublicHealth #PharmaMarketing #DrugDiscovery #SystemThinking
@promegauk.bsky.socialNew approach methodologies (NAMs) like organoids demand more from assays than traditional 2D methods can offer
Our colleague's Drug Target Review article explores six key requirements, including kinetic readouts, multiplexing and reproducibility - https://ow.ly/XV6I50ZSIki
@feworkshop.bsky.socialWestward bound: the 2027 Free Energy Workshop makes its West Coast debut at Merck Research Laboratories, in the heart of South San Francisco’s biotech corridor.
Stay tuned for more updates regarding keynote speakers and registration details!
#FreeEnergy #DrugDiscovery #CompChem @omsf.io
@stephanhacker2.bsky.socialInspiring talk by Scott Lovell at #CovModDrugDiscov.
He talked about the development of macrocyclic #peptides into covalent inhibitors targeting lysines using SuFEx chemistry.
www.biorxiv.org/content/10.6...
#DrugDiscovery #ChemSky #ChemBio #Science
@britpharmsoc.bsky.social
@stephanhacker2.bsky.socialInteresting talk by @ljwalport.bsky.social at #CovModDrugDiscov.
She talked about the discovery of potent peptide-based #CovalentInhibitors using mRNA display.
www.nature.com/articles/s42...
#mRNA #RNA #DrugDiscovery #ChemBio #ChemSky #Science
@britpharmsoc.bsky.social
@informaq.bsky.socialQuandela and Korea Research Institute of Bioscience and Biotechnology partnered to leverage photonic quantum computing, AI, and classical computing to accelerate drug discovery and tackle complex biological challenges.
@quartzmedia.bsky.socialAI Lab Promises to Supercharge Drug Discovery 8x ai-beat #AILab #DrugDiscovery #HealthcareInnovation #Biotech #MachineLearning
@quartzmedia.bsky.socialAn AI lab that never stops learning just entered drug discovery #ArtificialIntelligence #DrugDiscovery