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@tomkindlon.bsky.socialSep 25, 2026, 12:34 AM

From the UK

Bidirectional Associations Between Autonomic Function, Sleep Quality, & Daily Fatigue & Energy Symptoms in Long COVID: Longitudinal Digital Health Study

cardio.jmir.org/2026/1/e99630

s4me.info/threads/bidi...

Screenshot from Science for ME update

#LongCovid #PASC #PwLC #postcovid19

Bidirectional Associations Between Autonomic Function, Sleep Quality, and Daily Fatigue and Energy Symptoms in Long COVID: Longitudinal Digital Health Study — Aboagye et al. "sleep duration and REM sleep showed significant within-person (day-to-day) associations with next-day fatigue, and sleep efficiency showed a counterintuitive negative association with next-day energy" Article | Thread
@tomkindlon.bsky.socialSep 23, 2026, 12:32 AM

From Germany

Association of mRNA SARS-CoV-2 vaccination with fatigue and functional recovery in patients with post-acute sequelae of COVID-19 (PASC)

www.tandfonline.com/doi/abs/10.1...

Screenshot from latest Science for ME weekly update

#LongCovid #PASC #PwLC #postcovid #postcovid19

Association of mRNA SARS-CoV-2 vaccination with fatigue and functional recovery in patients with post-acute sequelae of COVID-19 (PASC) — Pries et al "Adults with […] PASC and at least two visits 3 to 6 months apart […] were eligible." "The exposure of interest was receipt of an additional SARS-CoV-2 vaccination" "we did not detect a statistically significant worsening of fatigue or exercise capacity" "Both vaccinated and non-vaccinated participants showed gradual improvement over time." Article | Thread
@tomkindlon.bsky.socialSep 22, 2026, 12:40 AM

From Sweden

Longitudinal epigenetic rewiring in lung immune cells in patients with post COVID-19 condition

link.springer.com/article/10.1...

s4me.info/threads/long...

Screenshot from latest Science for ME weekly update

#LongCovid #COVIDLung #PASC #PwLC #postcovid #postcovid19

Longitudinal epigenetic rewiring in lung immune cells in patients with post COVID-19 condition — Nikesjö et al "Distinct DNAm patterns were observed across pulmonary immune cell fractions, with longitudinal changes primarily detected in neutrophil- and macrophage-enriched populations, while alterations were not evident in PBMCs." "This divergence between lung and blood suggests tissue-specific epigenetic remodeling following SARS-CoV-2 infection and underscores the limitations of relying solely on peripheral blood to capture disease-relevant molecular changes in PCC." Article | Thread
@tomkindlon.bsky.socialSep 21, 2026, 4:49 PM

Press release from Karolinska Institutet (a medical university)

"Brain blood flow linked to fatigue after COVID-19"
news.ki.se/brain-blood-...

Paper:
www.sciencedirect.com/science/arti...

#LongCovid #NeuroPASC #COVIDBrain #PASC #PwLC #postcovid #postcovid19

Published: 15-09-2026 11:56 | Updated: 16-09-2026 13:37 Brain blood flow linked to fatigue after COVID-19 An AI-generated image depicting a woman holding her head in pain, surrounded by a crowd of people in rush-hour traffic. The image was generated using an AI tool. Photo: Sonia Miri Hedberg,AI-genererad bild People with post-COVID-19 condition reported higher levels of fatigue and showed slower reaction times than healthy individuals. A new study from Karolinska Institutet, published in NeuroImage: Reports, also found lower blood flow in several parts of the brain, which may be linked to the cognitive difficulties experienced by many people after COVID-19.
@tomkindlon.bsky.socialSep 21, 2026, 12:23 AM

From Sweden

Cognitive fatigue is related to reduced cerebral perfusion & sustained attention in patients with post COVID-19 condition: An fMRI study

www.sciencedirect.com/science/arti...

Screenshot from Science for ME update

#LongCovid #NeuroPASC #COVIDBrain #PASC #PwLC #postcovid #postcovid19

Cognitive fatigue is related to reduced cerebral perfusion and sustained attention in patients with post COVID-19 condition: An fMRI study — Hedberg et al "Perfusion analysis revealed reduced CBF, not only in several regions but also globally across the whole brain and correlated with overall reaction time as well as individual performance variability" Article | Thread
@tomkindlon.bsky.socialSep 15, 2026, 1:21 PM

From the Netherlands

A brief report: absence of elevated circulating NETosis markers in long-term long COVID

www.frontiersin.org/journals/cel...

Screenshot from latest Science for ME weekly update

#LongCovid #PASC

A brief report: absence of elevated circulating NETosis markers in long-term long COVID — Humer et al "Plasma levels of MPO-DNA, histone-DNA and citrullinated histone H3 (H3) did not differ significantly between LC and HC." "No significant associations were observed between NETosis marker concentrations and symptom severity measures and core LC symptoms." Article | Thread
@tomkindlon.bsky.socialSep 15, 2026, 12:13 AM

From Poland

Microvascular Dysfunction and Redox Imbalance in Long COVID

onlinelibrary.wiley.com/doi/10.1111/...

s4me.info/threads/micr...

Screenshot from latest Science for ME weekly update

#LongCovid #PASC

Microvascular Dysfunction and Redox Imbalance in Long COVID — Lewandowska et al "We observed a reduced erythrocyte NAD+/NADH ratio and lower NADP concentrations" "At the circulating level, this metabolic pattern was characterized by reduced availability of NAD+ precursors and metabolites (NA, MNA, NR) together with accumulation of downstream degradation products, including 4PYR and Met2PY." Article | Thread
@tomkindlon.bsky.socialSep 14, 2026, 7:25 PM

Long Covid Kids @longcovidkids.bsky.social have developed resources for children and parents including an Individual Healthcare Plan (IHCP) template, available for download as Word or PDF

www.longcovidkids.org/download-res...

Screenshot from Science for ME update

#LongCovid #LongCovidKids #PASC

UK Long Covid Kids have developed resources for children and parents including an Individual Healthcare Plan (IHCP) template, available for download as Word or PDF. It is intended to be filled in for each child with long Covid or related conditions to provide schools with information about the child's needs for adjustments and support at school. Website with links | Thread
@tomkindlon.bsky.socialSep 12, 2026, 6:26 PM

From Singapore

Case Report: Post-Mortem Analysis of Long-Term Inflammation After Mild COVID-19

www.frontiersin.org/journals/imm...

s4me.info/threads/case...

Screenshot from latest Science for ME weekly update

#LongCovid #PASC

Case Report: Post-Mortem Analysis of Long-Term Inflammation After Mild COVID-19 — Wu et al "Notably, in contrast to early epidemiological studies which established PACS as a multisystem disorder, our findings extend these observations by providing tissue-level evidence that persistent viral antigen and spatially organized immune activation can remain detectable in specific organs, more than 250 days after mild acute disease." Article | Thread
@tomkindlon.bsky.socialSep 12, 2026, 2:17 PM

From Switzerland

Measurement properties of the 30-second sit-to-stand test in post COVID-19 condition: Results from the PYCNOVID randomised controlled trial

journals.plos.org/plosone/arti...

s4me.info/threads/meas...

Screenshot from latest Science for ME weekly update

#LongCovid #PASC

Measurement properties of the 30-second sit-to-stand test in post COVID-19 condition: Results from the PYCNOVID randomised controlled trial — Braun et al "Consistent with our hypothesis, boxplots of STS performance across the four PEM grades suggested that individuals with very severe PEM completed fewer 30s-STS repetitions, whereas the other three PEM groups displayed comparable values." Article | Thread
@tomkindlon.bsky.socialSep 11, 2026, 6:29 PM

Microbiome dysbiosis in long COVID: a scoping review of mechanistic insights, symptom associations, and therapeutic targets

Screenshot from latest Science for ME weekly update

link.springer.com/article/10.1...

#LongCovid #PASC

Microbiome dysbiosis in long COVID: a scoping review of mechanistic insights, symptom associations, and therapeutic targets — Cano-Cevallos et al "These findings have been described in association with systemic inflammation, immune dysregulation, and disruptions in gut–lung and gut–brain axis signaling; however, these relationships are largely based on observational data and conceptual interpretations rather than confirmed causal mechanisms." Article | Thread
@tomkindlon.bsky.socialSep 11, 2026, 4:52 PM

From Turkey

Persistent fibroblast-related tissue activity in long COVID after moderate-to-severe acute COVID-19 assessed by [⁶⁸Ga]Ga-FAPI PET/CT

Screenshot from latest Science for ME weekly update

www.sciencedirect.com/science/arti...

s4me.info/threads/pers...

#LongCovid #PASC

Persistent fibroblast-related tissue activity in long COVID after moderate-to-severe acute COVID-19 assessed by [⁶⁸Ga]Ga-FAPI PET/CT — Hasan et al "The paravertebral muscle [⁶⁸Ga]Ga-FAPI SUVmax was significantly higher in PASC patients compared to controls (median: 6.35 vs. 3.65; p < 0.001)." Article | Thread
@tomkindlon.bsky.socialSep 7, 2026, 11:22 PM

A new U.S. clinical trials program called PROBE-PASC was announced at the conference in Amsterdam

thesicktimes.org/2026/09/01/d...

Screenshot from latest Science for ME weekly update

#LongCovid #PASC

The Sick Times A new U.S. clinical trials program called PROBE-PASC was announced at the conference in Amsterdam. The program received initial funding of $8 million from a Department of Defense (DOD) grant. The first clinical trial in the series will test the monoclonal antibody Pemgarda, along with the immune-modulating drug hydroxychloroquine. Article | Thread
@tomkindlon.bsky.socialSep 6, 2026, 9:23 PM

“For Many Americans, Covid Is Still a Chronic, Disabling Disease. These Scientists Are Working Tirelessly to Bring Them Relief” (Smithsonian magazine) by Mike Mariani

www.smithsonianmag.com/innovation/m...

Feature article on research into Long Covid.

#LongCovid #PASC #PostCovid #PostCovid19