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@tomkindlon.bsky.socialOct 9, 2026, 12:02 AM

From Ireland

Characterizing Host Inflammatory Bioprofiles in People With Postacute Sequelae SARS-CoV-2 Infection (PASC)

onlinelibrary.wiley.com/doi/10.1155/...

Screenshot from latest Science for ME weekly update

#LongCovid #PASC #PwLC #postcovid #postcovid19

Characterizing Host Inflammatory Bioprofiles in People With Postacute Sequelae SARS-CoV-2 Infection (PASC) — Marmont et al "six distinct inflammatory clusters were identified within people with PASC, three of which showed elevated biomarkers related to tissue damage and repair, coagulation, axonal injury, and antiviral immune responses and were associated with component 3 of the complement pathway." Article | Thread
@tomkindlon.bsky.socialOct 8, 2026, 11:51 PM

From the US

Neurocognitive Indices of Long COVID: Dysregulated Engagement of Inhibitory Control and Oscillatory Slowing

www.mdpi.com/2673-4087/7/...

Screenshot from latest Science for ME weekly update

#LongCovid #NeuroPASC #COVIDBrain #PASC #PwLC #postcovid #postcovid19

Neurocognitive Indices of Long COVID: Dysregulated Engagement of Inhibitory Control and Oscillatory Slowing — White et al "Taken together, these findings clearly indicate that even mild PASC is associated with significant alterations in cell signaling, characterized by oscillatory slowing." Article | Thread
@tomkindlon.bsky.socialOct 8, 2026, 12:46 AM

From Germany

Brain-binding auto-antibodies in subjects with and without post-COVID-syndrome after SARS-CoV-2 infection

www.sciencedirect.com/science/arti...

Screenshot from latest Science for ME weekly update

#LongCovid #NeuroPASC #PASC

Brain-binding auto-antibodies in subjects with and without post-COVID-syndrome after SARS-CoV-2 infection — Faraj et al "Our data further support the conjecture of a dysregulated immune system after COVID-19, and endorse former observations that there is no direct link between autoantibody prevalence and clinical symptoms of Post-COVID syndrome." Article | Thread
@tomkindlon.bsky.socialOct 6, 2026, 1:29 AM

From Austria

Remnant virus proteins sustain vascular inflammation post coronavirus infection in mice and humans

portlandpress.com/clinsci/arti...

Screenshot from latest Science for ME weekly update

#LongCovid #PASC #PwLC

Remnant virus proteins sustain vascular inflammation post coronavirus infection in mice and humans
@tomkindlon.bsky.socialOct 6, 2026, 1:22 AM

From Austria

Hair cortisol concentration and basal heart rate variability differentiate long COVID from depressive disorders in youth

www.sciencedirect.com/science/arti...

Screenshot from latest Science for ME weekly update

#LongCovid #depression #Dysautonomia #NeuroPASC #PASC

Hair cortisol concentration and basal heart rate variability differentiate long COVID from depressive disorders in youth — Oehlke et al "Without a healthy reference, it cannot be determined whether HCC or HRV indices in either clinical group deviate from normative physiological levels, nor whether the observed patterns are specific to LC or depressive disorders. Accordingly, the present findings should be understood as relative differences between the two clinical groups." Article | Thread
@tomkindlon.bsky.socialOct 6, 2026, 1:15 AM

From Ireland

Dysautonomia and Postural Orthostatic Syndrome of Hypocapnia in Long COVID Syndrome

Screenshot from latest Science for ME weekly update

#LongCovid #POTS #Dysautonomia #NeuroPASC #PASC

Dysautonomia and Postural Orthostatic Syndrome of Hypocapnia in Long COVID Syndrome — O’Brien et al "Patients from this cohort with LCS, dysfunctional breathing and hypocapnia based on the lean test were referred for targeted pulmonary rehab." "There was no significant change in end-tidal CO2 or heart rate following the intervention." Article | Thread
@tomkindlon.bsky.socialOct 6, 2026, 12:33 AM

From the US

Autoantibody landscapes in Long COVID with neurological symptoms show heterogeneity without a shared disease signature

insight.jci.org/articles/vie...

Screenshot from latest Science for ME weekly update

#LongCovid #NeuroPASC #PASC

Autoantibody landscapes in Long COVID with neurological symptoms show heterogeneity without a shared disease signature — Chakravarty et al "Across tissue-based assays and peptide-level, whole-human-proteome PhIP-Seq profiling, the data consistently reveal a lack of convergent, disease-specific autoantibody signatures." Article | Thread
@tomkindlon.bsky.socialOct 2, 2026, 12:41 AM

From Sweden

Booster dose of COVID-19 vaccine and its effectiveness against post COVID-19 condition in individuals with pre-existing immunity

www.thelancet.com/journals/ecl...

Screenshot from Science for ME update

#LongCovid #PASC #PwLC #postcovid #postcovid19 #PostCovidSyndrome

Booster dose of COVID-19 vaccine and its effectiveness against post COVID-19 condition in individuals with pre-existing immunity: a sequential propensity score-matched cohort study — Morris et al "we demonstrate that receiving a fourth dose of COVID-19 vaccine is associated with a decreased risk of being diagnosed with post COVID-19 condition during the first 6 months after vaccination, although the incidence rate difference was small." Article | Thread
@tomkindlon.bsky.socialOct 1, 2026, 12:34 AM

From the UK

An Open-Label Feasibility Study of Remdesivir in Long COVID: Results from the ERASE LC Trial

dx.doi.org/10.1093/oxfi...

Screenshot from latest Science for ME weekly update

#LongCovid #PASC #PwLC #postcovid #postcovid19

An Open-Label Feasibility Study of Remdesivir in Long COVID: Results from the ERASE LC Trial — Faghy et al "The mean (SD) distance achieved in the 6MWT was 408 (113) metres at baseline compared to 468 (109) metres post-intervention" "whilst improvements were observed in health-related quality of life, the mean change in EQ-5D-5L index score (0.06) did not exceed the published MCID of 0.11" "Improvements could reflect natural fluctuation in symptom burden, behavioural modification associated with trial participation, or expectation effects." Article | Thread
@tomkindlon.bsky.socialSep 30, 2026, 12:30 AM

The Post-Acute Effects of COVID-19 Are Not Associated with Robust Long-Term Regional or Global Brain Volumetric Changes: A Bayesian Meta-Analytic Evidence

www.sciencedirect.com/science/arti...

Screenshot from Science for ME update

#LongCovid #NeuroPASC #COVIDBrain #PASC #postcovid #postcovid19

The Post-Acute Effects of COVID-19 Are Not Associated with Robust Long-Term Regional or Global Brain Volumetric Changes: A Bayesian Meta-Analytic Evidence — Costa et al "our focused examination of both global and regional volumetric changes not only provides deeper spatial insights compared to previous primary studies but also addresses the substantial methodological heterogeneity" "Results highlighted that while either global or local alteration was reported by independent studies, this evidence remains unsupported when they are considered on a meta-analytic level."
@heytheremaggs.bsky.socialSep 29, 2026, 5:15 PM

Hi #LongCovid / #MECFS friends. What is the going feeling on the actively recruiting phase 3 Baricitinib trial?

#NEISvoid #ClinicalTrial #Study #Science #Covid #RCT #REVERSE-LC #PostCovid #Covid19 #PASC #MoHashtagsMoProblems

@monalisarout1701.bsky.socialSep 28, 2026, 6:08 AM

Paxlovid in Acute COVID-19: PASC Prevention Insights
🔹 445,738 patients examined
🔸 Negligible effect on overall PASC

#PASC #COVID19 #Paxlovid https://tnyp.me/f8Q353pu/s

@monalisarout1701.bsky.socialSep 28, 2026, 6:04 AM

Paxlovid in Acute COVID-19: PASC Prevention Insights
🔹 445,738 patients examined
🔸 Negligible effect on overall PASC

#PASC #COVID19 #Paxlovid https://tnyp.me/f8Q353pu/s

@tomkindlon.bsky.socialSep 25, 2026, 5:16 PM

NEWS RELEASE 23-SEP-2026

UTHealth Houston database fills gap in Long COVID surveillance

www.eurekalert.org/news-release...

#LongCovid #PASC

@tomkindlon.bsky.socialSep 25, 2026, 5:15 PM

NEWS RELEASE 23-SEP-2026

UTHealth Houston database fills gap in Long COVID surveillance

www.eurekalert.org/news-release...

#LongCovid #PASC

@tomkindlon.bsky.socialSep 25, 2026, 12:34 AM

From the UK

Bidirectional Associations Between Autonomic Function, Sleep Quality, & Daily Fatigue & Energy Symptoms in Long COVID: Longitudinal Digital Health Study

cardio.jmir.org/2026/1/e99630

s4me.info/threads/bidi...

Screenshot from Science for ME update

#LongCovid #PASC #PwLC #postcovid19

Bidirectional Associations Between Autonomic Function, Sleep Quality, and Daily Fatigue and Energy Symptoms in Long COVID: Longitudinal Digital Health Study — Aboagye et al. "sleep duration and REM sleep showed significant within-person (day-to-day) associations with next-day fatigue, and sleep efficiency showed a counterintuitive negative association with next-day energy" Article | Thread
@tomkindlon.bsky.socialSep 23, 2026, 12:32 AM

From Germany

Association of mRNA SARS-CoV-2 vaccination with fatigue and functional recovery in patients with post-acute sequelae of COVID-19 (PASC)

www.tandfonline.com/doi/abs/10.1...

Screenshot from latest Science for ME weekly update

#LongCovid #PASC #PwLC #postcovid #postcovid19

Association of mRNA SARS-CoV-2 vaccination with fatigue and functional recovery in patients with post-acute sequelae of COVID-19 (PASC) — Pries et al "Adults with […] PASC and at least two visits 3 to 6 months apart […] were eligible." "The exposure of interest was receipt of an additional SARS-CoV-2 vaccination" "we did not detect a statistically significant worsening of fatigue or exercise capacity" "Both vaccinated and non-vaccinated participants showed gradual improvement over time." Article | Thread
@tomkindlon.bsky.socialSep 22, 2026, 12:40 AM

From Sweden

Longitudinal epigenetic rewiring in lung immune cells in patients with post COVID-19 condition

link.springer.com/article/10.1...

s4me.info/threads/long...

Screenshot from latest Science for ME weekly update

#LongCovid #COVIDLung #PASC #PwLC #postcovid #postcovid19

Longitudinal epigenetic rewiring in lung immune cells in patients with post COVID-19 condition — Nikesjö et al "Distinct DNAm patterns were observed across pulmonary immune cell fractions, with longitudinal changes primarily detected in neutrophil- and macrophage-enriched populations, while alterations were not evident in PBMCs." "This divergence between lung and blood suggests tissue-specific epigenetic remodeling following SARS-CoV-2 infection and underscores the limitations of relying solely on peripheral blood to capture disease-relevant molecular changes in PCC." Article | Thread
@tomkindlon.bsky.socialSep 21, 2026, 4:49 PM

Press release from Karolinska Institutet (a medical university)

"Brain blood flow linked to fatigue after COVID-19"
news.ki.se/brain-blood-...

Paper:
www.sciencedirect.com/science/arti...

#LongCovid #NeuroPASC #COVIDBrain #PASC #PwLC #postcovid #postcovid19

Published: 15-09-2026 11:56 | Updated: 16-09-2026 13:37 Brain blood flow linked to fatigue after COVID-19 An AI-generated image depicting a woman holding her head in pain, surrounded by a crowd of people in rush-hour traffic. The image was generated using an AI tool. Photo: Sonia Miri Hedberg,AI-genererad bild People with post-COVID-19 condition reported higher levels of fatigue and showed slower reaction times than healthy individuals. A new study from Karolinska Institutet, published in NeuroImage: Reports, also found lower blood flow in several parts of the brain, which may be linked to the cognitive difficulties experienced by many people after COVID-19.
@tomkindlon.bsky.socialSep 21, 2026, 12:23 AM

From Sweden

Cognitive fatigue is related to reduced cerebral perfusion & sustained attention in patients with post COVID-19 condition: An fMRI study

www.sciencedirect.com/science/arti...

Screenshot from Science for ME update

#LongCovid #NeuroPASC #COVIDBrain #PASC #PwLC #postcovid #postcovid19

Cognitive fatigue is related to reduced cerebral perfusion and sustained attention in patients with post COVID-19 condition: An fMRI study — Hedberg et al "Perfusion analysis revealed reduced CBF, not only in several regions but also globally across the whole brain and correlated with overall reaction time as well as individual performance variability" Article | Thread
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