African proteomic study unlocks Alzheimer's insights. Nigerian and Tanzanian cohorts reveal plasma profiles linked to amyloid pathology; breakthrough in ADRD research! PMID:42386726, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74971-4 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Boost T cell therapy! Targeting CD2/CD7 increases nanoparticle delivery to CD4+ T cells—significantly higher uptake versus CD3/CD28. Transforming treatments! PMID:42386746, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74981-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

LEAPER 3.0 enhances RNA editing via engineered ADAR-recruiting RNAs. It leverages AlphaFold 3 for precision, expanding efficient editing strategies. PMID:42269608, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00514-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Discovering a Buchnera protein key for host cell colonization boosts understanding of endosymbiont entry and immune suppression in insects! PMID:42386962, Nature 2026, @Nature https://doi.org/10.1038/s41586-026-10711-4 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Discovering the Plasmodium moving junction structure unveils a sailboat-shaped 1:1:1:1 assembly of PfAMA1 with PfRON2, PfRON4, and PfRON5, crucial for malaria invasion! PMID:42379167, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00699-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Counting down to #SEBD2026! 🎉 First up in our speaker spotlight series: Opening Keynote Antonio Giraldez (Yale University), a pioneer in #DevelopmentalBiology and #RNA regulation. His groundbreaking work revealed how #microRNAs control the maternal-to-zygotic transition

Wang et al. reveal that excessive vascular integrity in small-cell lung cancer creates immune desertification; they propose "reverse normalization" to enhance immunity and tackle immunotherapy resistance. PMID:42349379, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00634-3 #RNA 🧪

RESEARCH PAPER: Multimerization of ELAV in Drosophila is essential for directing neuronal alternative splicing and polyadenylation programs
By Dix, McQuarrie, Bräuer et al. and Matthias Soller
➡️ https://genesdev.cshlp.org/content/40/19-20/1669.abstract

Matthias Soller
#RNA #neuron #Drosophila

Heat stress increases susceptibility to metabolic dysfunction in mice on an obesogenic diet. Elevated skin-derived KLK14 affects hypothalamic LRRC7+ astrocytes. PMID:42019490, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00346-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A novel model reveals mammalian cortical connectomes exhibit ⌀ topology influenced by physical constraints, focusing connectivity into distinct regions. PMID:42361798, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00648-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A new method, variant in situ sequencing (VIS-seq), measures effects of ~3,000 LMNA & PTEN variants, revealing complex, high-dimensional phenotypes in cell architecture. PMID:42127894, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00466-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Interesting talk by @ljwalport.bsky.social at #CovModDrugDiscov.

She talked about the discovery of potent peptide-based #CovalentInhibitors using mRNA display.

www.nature.com/articles/s42...

#mRNA #RNA #DrugDiscovery #ChemBio #ChemSky #Science
@britpharmsoc.bsky.social

Nuclear metabolism links to gene regulation: ACO2 & IDH2 localize in the nucleus, catalyzing α-ketoglutarate reductive carboxylation for histone acetylation & gene activation. PMID:42386731, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74786-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Elevated FAM3D levels correlate with atherosclerosis; reducing Fam3d in mice cuts intestinal cholesterol & triglyceride absorption by 30%+! PMID:42385709, Cell Rep Med 2026 https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(26)00325-3?rss=yes&utm_source=dlvr.it&utm_medium=twitter #RNA 🧪

Synthetic mRNA with N⁴-Acetylcytidine boosts translation yield, fidelity, and stability. Outperforms standard m¹Ψ in cancer and infection treatments. PMID:42386968, Nature 2026, @Nature https://doi.org/10.1038/s41586-026-10729-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Cisplatin, a cancer treatment, triggers DNA damage in neurons via NER, leading to cell death rather than protection, revealing a critical vulnerability in post-mitotic tissues. PMID:42269607, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00584-2 #Medsky #Pharmsky #RNA #ASHG 🧪

New insights: Coccidioides arthroconidia activate TLR2 and induce NLRP3-pyrin inflammasomes in macrophages. Ferroptotic signaling aids fungal killing. Stay informed! PMID:42386736, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-75022-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Transposable elements shape our genome by associating with epigenomic marks across 4867 ChIP datasets, influencing regulatory roles in various cell types. PMID:42386716, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74920-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

50% of human fertilized eggs fail to develop due to error-prone second mitotic divisions. Stochastic centriole overduplication leads to arrest, effectively reduced by PLK4 inhibition. PMID:42276044, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00637-9 #Medsky #Pharmsky #RNA 🧪

A 14-protein plasma signature predicts lung cancer risk >5 years pre-diagnosis, enhancing prevention efforts beyond the CANTOS trial's NNT limitations. #CancerResearch PMID:42242224, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00522-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪