@matthiassoller.bsky.social
Professor of RNA Biology FBMH University of Manchester
Molecular geneticist interested in RNA regulation in the brain using mighty Drosophila fruit flies
Epitranscriptomics Phylogenomics Neuro-connectomics ELAV Dscam Sex-peptide Synapse
www.sollerlab.org
@rridrobot.bsky.socialReposted by @matthiassoller.bsky.socialRRIDs were included in this in Nature Communications paper. RRIDs improve reproducibility in scientific research. #methodsmatter #RRID #STMpublishing
@grzechnikpawel.bsky.socialReposted by @matthiassoller.bsky.socialTranscription termination can be targeted by antisense oligonucleotides!
In collaboration with Roche Innovation Center Basel, we describe downstream-of-gene ASOs (DG-ASOs), which act within transcription termination windows, OUTSIDE of annotated genes.
@matthiassoller.bsky.socialA 0.1% fee on all finance transactions could potentially raise £548 billion in revenue in the UK. Per average UK household this is 2£ of tax a month. Why are we not doing this?
@plaschkalab.bsky.socialReposted by @matthiassoller.bsky.socialAfter excising an intron, the spliceosome gets trapped on the branched intron-lariat RNA. How are such dead-end spliceosomes terminated? Our latest paper led by @vytaute.bsky.social investigates the mechanism of spliceosome termination www.nature.com/articles/s41... (1/6)
@labwaggoner.bsky.socialReposted by @matthiassoller.bsky.socialRibosome remodeling drives translation adaptation during viral infection and cellular stress @cp-molcell.bsky.social
www.cell.com/molecular-ce...
@matthiassoller.bsky.socialIndeed an enjoyable read! Highly recommended.
@robertarkowitz.bsky.socialReposted by @matthiassoller.bsky.social@matthiassoller.bsky.socialExcited to share our new paper thanks to Tom Dix, @davidmcquarrie.bsky.social @yuantian23.bsky.social and the others @mcf-uom.bsky.social @fbmh-uom.bsky.social @manchester.ac.uk about multimerization of prototype RRM ELAV/Hu family RNA binding proteins.
@flybehaviour.bsky.socialReposted by @matthiassoller.bsky.socialCool new paper from @joshdubnau.bsky.social
Early life social isolation primes flies for rapid neurodegeneration later in life.
@mariahondele.bsky.socialReposted by @matthiassoller.bsky.socialNuclear speckles are “hot”, but how do they actually sequester mRNPs?
We find that stalled mRNPs are retained in nuclear speckles by a combinatorial RNA-binding protein network.
www.biorxiv.org/content/10.6...
@willgarland.bsky.socialReposted by @matthiassoller.bsky.socialNew from the lab! We uncover how the cap-binding complex promotes first-intron splicing: ZC3H18 recruits splicing factors while competing with the RNA-decay machinery, linking two alternative fates for newly made RNA.
doi.org/10.1016/j.mo...
@obataf-lab.bsky.socialReposted by @matthiassoller.bsky.socialOur new study just out @nature.com Together with Koshi Imami @RIKEN IMS, Hina Kosakamoto found out the key molecule mediating lifespan extension by early life dietary restriction! www.nature.com/articles/s41...
@matthiassoller.bsky.socialTop story on TOP mRNAs!
www.nature.com/articles/s41...
@simonbullock11.bsky.socialReposted by @matthiassoller.bsky.socialHow are mRNAs linked to molecular motors in mammalian cells? In our new preprint, we show that FXR1/2 are RNA adaptors for the microtubule motor dynein. Our findings have also prompted us to rethink how activating adaptors contribute to motor-based transport (1/n)
@matthiassoller.bsky.socialFancy RNA processing - Here is the structure of the Editosome from Trypanosomes doing U insertions and deletions.
www.nature.com/articles/s41...
@interactivefly.bsky.socialReposted by @matthiassoller.bsky.socialChen, Y., Hu, J., Zhao, P., Fang, J., Kuang, Y., Liu, Z., ...., Tang, K., Yang, B., Liu, W., Sun, Q., Mei, K., Zou, W., Huang, Y., Feng, D., Yi, C. (2025). Rpl12 is a conserved ribophagy receptor. Nat Cell Biol, 27(3):477-492 www.nature.com/articles/s41...
@kisungpark.bsky.socialReposted by @matthiassoller.bsky.social
@genomebrowser.bsky.socialReposted by @matthiassoller.bsky.socialNew public hub: Sci-ModoM RNA modification sites. 7.9M m6A, pseudouridine, m5C and 2'-O-methylation sites on hg38 and mm39, each with its coverage and percent modified.
Explore hub: genome.ucsc.edu/s/Lo...
More public hubs: genome.ucsc.edu/cgi-...
@rnamod.bsky.socialReposted by @matthiassoller.bsky.socialTranscript-wide m6A methylation defines the efficiency of cap-independent translation initiation
RNA (New York, N.Y.) · Smolin et al.
doi.org/10.1261/rna.081017.126
#RNAsky #RNAmods
@rnamod.bsky.socialReposted by @matthiassoller.bsky.socialRNA demethylase FTO uses conserved aromatic residues to recognize the mRNA 5' cap and promote efficient m6Am demethylation
The Journal of biological chemistry · Shimanski et al.
doi.org/10.1016/j.jbc.2026.113573
#RNAsky #RNAmods