📣 Deadline extension: The abstract submission deadline for 2027 AAP/ASCI/APSA Joint Meeting has been extended to October 26th!
👉 buff.ly/Iq6VZFY

📣 Call for posters: The ASCI is now accepting abstract submissions for the 2027 AAP/ASCI/APSA Joint Meeting
Deadline: October 12, 2026
More info: buff.ly/Iq6VZFY

ASCI member Chirag R. Parikh & team recently published in JCI Insight!
In this peek Behind the Paper, authors Serena D. Souza and Wassim Obeid work on the new urine test that may help with earlier diagnosis for the rare kidney disease cystinosis in children 📎: doi.org/10.1172/jci....

📣 Nominations are OPEN
for the 2027-2029 ASCI Postbaccalaureate Program!!

🔹 2 Postbacs Awarded
🔹 2 year laboratory research experience
🔹 ASCI-member lab
🔹 Immersive and mentored
🔹 MCAT and Med School Application Prep
Learn more: buff.ly/uF7BsNQ

Suggesting a novel therapy for systemic sclerosis: doi.org/10.1172/jci....
@eduardomarban.bsky.social & team report that an orally delivered noncoding RNA (TY1) reduces inflammation and organ fibrosis in models of systemic sclerosis through inhibition of the cGAS/STING axis.
@the-asci.org

📣 Nominations are OPEN
for the 2027-2028 ASCI PSSF Fellowship Program!!
🔸 5 Fellowships Awarded
🔸 MD-or DO-only medical students
🔸 Med school research gap year (12 months)
🔸 Physician-scientist track
🔸 Immersive and mentored
Learn More: buff.ly/0bsi5B8

Proposing a combination treatment for reducing death from cerebral malaria: doi.org/10.1172/JCI2...

Alvin H. Schmaier & team report on a role for bradykinin in cerebral malaria and find plasma kallkrein inhibitors target host-mediated vascular dysfunction.
@the-asci.org

Changing the paradigm for loss of the Y chromosome: doi.org/10.1172/jci....

Dan Theodorescu & team report Y chromosome loss increases progressively from healthy tissues to cancer, suggesting it is an early and previously unrecognized driver of cancer development.
@the-asci.org

Congratulations to ASCI member Masashi Yanagisawa for the Lasker prize @laskerfdn.bsky.social!
Mignot and Yanagisawa are recognized for their discovery of the role of orexins/hypocretins in wake, sleep, and narcolepsy. Yanagisawa previously presented at the ASCI scientific session: buff.ly/kJKbBLY

Mignot and Yanagisawa win the Lasker prize from from @laskerfdn.bsky.social for discovery of the role of orexins/hypocretins in wake, sleep, and narcolepsy: doi.org/10.1172/JCI2...

In this Viewpoint, Clifford B. Saper places Mignot’s and Yanagisawa’s discoveries in a historical context.

Alpha-Gal syndrome is a tick bite-associated allergy characterized by reactions to alpha-Gal found in red meat

doi.org/10.1172/JCI1...
Peter D. Crompton & team show the potential of alpha-Gal-specific mAbs to prevent the allergy by blocking IgE binding to alpha-Gal.
@the-asci.org

Welcome to the kidney!
R Ariel Gomez & team examine the role of renin cells in renal neurovascular morphogenesis & remodeling. The video: mouse kidney cortex with renin cells (magenta), the renal arterial tree (green), nerve fibers (yellow): doi.org/10.1172/jci....
@the-asci.org

Early signals shape cardiac macrophage phenotypes & repair outcomes: doi.org/10.1172/JCI1...
Kory J Lavine & team traced monocyte differentiation trajectories after injury & identified an MHCIIhi population with an early IFN response signature associated with enhanced cardioprotection
@the-asci.org

This proteomic score outperforms widely used clinical risk models: doi.org/10.1172/jci....

Corey et al. report on blood proteins that help predict heart disease risk in diabetes and are modified by GLP-1 therapy, improving risk assessment beyond traditional clinical factors.
@the-asci.org

A new approach for kicking osteoarthritis: doi.org/10.1172/jci....

Wen Jiang @wenjiang-nano.bsky.social @mdanderson.bsky.social & team find blocking a key immune sensor, NOD2, in cartilage cells reduces joint damage in osteoarthritis mouse models.
@the-asci.org