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High-quality, topflight, and clinically impactful basic and translational research representative of all biomedical specialties and physician-scientists: https://insight.jci.org/
@insight.jci.orgTheir work is featured on the Cover, showing liver tissue in which fibrosis (orange) emanates from central veins that were identified by EC zonation markers Endomucin (cyan) and Thrombomodulin (magenta). Image credit: Christina Gkantsinikoudi and Neil Dufton: doi.org/10.1172/jci....
@insight.jci.orgGkantsinikoudi et al. mapped blood vessel changes during fibrosis and identified markers that could help predict liver disease at earlier stages than current clinical tests. doi.org/10.1172/jci....
@insight.jci.orgWeekend Highlight💫: Behind the Paper: Dufton Group members (1/2) Dr. Meenakshi Rana, Dr. Neil Dufton, Dr. Joshua Dignam, and Dr. Christina Gkantsinikoudi (left to right). And first author Dr. Christina Gkantsinikoudi at the bench (2/2).
@neildufton.bsky.socialReposted by @insight.jci.orgFantastic to not only see the final version of the paper published but also have it featured on the cover of the October issue of @insight.jci.org 🎉🎉🎉 #endothelialcells #liver #fibrosis
@insight.jci.orgMitochonic acid-5 alleviates amyotrophic lateral sclerosis phenotypes via mitochondrial augmentation: doi.org/10.1172/jci....
@insight.jci.orgBehind the paper: Dr. Toyohara and Dr. Oikawa are discuss the extracellular flux analysis experiment (1/3) and future research plans (2/3), while Dr. Kuranaga and Ms. Yuhan Luo consider Drosophila experiments (3/3).
@insight.jci.orgSpotlight💫: This video shows the restoration of mitochondrial motility in ALS iPS-derived motor neurons.
Oikawa et al. report the MA-5 improves mitochondrial function and ameliorates ALS phenotypes in Drosophila, patient-derived fibroblasts, and iPSC-derived motor neurons: doi.org/10.1172/jci....
@insight.jci.orgTime-restricted feeding reverses kidney fibrosis through reduced CD8+ T cell infiltration in obese mice: doi.org/10.1172/jci....
@insight.jci.orgAnother piece of the pie for time restricted feeding: doi.org/10.1172/jci....
Edell et al. discover time-restricted feeding reverses kidney fibrosis in obese mice by reducing CD8+ T cell infiltration.
@insight.jci.orgMapping a path for predicting liver disease at earlier stages than current tests: doi.org/10.1172/jci....
@neildufton.bsky.social & team @qmulwhri.bsky.social mapped blood vessel changes during fibrosis & identified markers that could help predict early-stage liver disease.
@timkendall.bsky.social
@insight.jci.orgCenatus et al. describe a novel role for SMOC2 in promoting partial epithelial-to-mesenchymal transition and maladaptive repair mechanisms in renal tubular epithelial cells: doi.org/10.1172/jci....
@fondsrechercheqc.bsky.social
@insight.jci.orgChronic hypertension impairs lymphatic drainage in deep cervical lymph nodes: doi.org/10.1172/jci....
@insight.jci.orgTracing the effects of high blood pressure on the brain: doi.org/10.1172/jci....
Xu et al. use a novel computational MRI imaging framework in rats to show that chronic high blood pressure impairs lymph node drainage of brain-derived fluids.
@insight.jci.orgThe monoclonal antibody VYD2311 is in clinical trials for preventing COVID-19.
In this Research Letter, @ianmellis.bsky.social et al. report that a laboratory-synthesized version of it inhibits many SARS-CoV-2 variants in laboratory-based infection models: doi.org/10.1172/jci....
@insight.jci.orgA finding in mice suggests a new target for severe COVID-19: doi.org/10.1172/jci....
Eltobgy et al. discover that blocking the inflammatory protein caspase-11 restores virus-fighting T cells and improves viral clearance in mice.
@insight.jci.orgWeekend read💫 : Immune cells ring the alarm! doi.org/10.1172/jci....
Hongji Zhang use a multiomic approach to investigate the drivers of surgical stress in the liver. They identify a neutrophil-Kupffer cell communication axis with potential for reducing inflammation and liver damage.
@insight.jci.orgFeatured on the Cover: IFNG-producing self-reactive CD4+ T cells induce autoimmune adrenalitis in a mouse model of Addison’s disease: doi.org/10.1172/jci....
@insight.jci.orgSaturday Spotlight💫: Presenting the first mouse model of Addison’s disease: doi.org/10.1172/jci....
Andreyeva et al. report on how immune cells destroy the adrenal glands in Addison's disease and identify IFNG as a promising target for future therapies.
@insight.jci.orgMitochonic acid-5 alleviates amyotrophic lateral sclerosis phenotypes via mitochondrial augmentation: doi.org/10.1172/jci....
@insight.jci.orgBehind the paper: Dr. Toyohara and Dr. Oikawa are discuss the extracellular flux analysis experiment (1/3) and future research plans (2/3), while Dr. Kuranaga and Ms. Yuhan Luo consider Drosophila experiments (3/3).
