@jci.org
The JCI is a premiere venue for discoveries in basic and clinical biomedical science that will advance the practice of medicine. Est. 1924
@jci.org@hellmutaugustin.bsky.social & team @uniheidelberg.bsky.social find ectodomain cleavage of the vascular receptor Tie1 distinguishes the inflammatory from the angiogenic functions of Angiopoietin-Tie signaling, uncoupling two fundamental vascular programs: doi.org/10.1172/JCI2...
@jci.orgNoncanonical mTORC1-TFEB activation promotes hepatocyte plasticity and high-grade malignancy in hepatocellular carcinoma: doi.org/10.1172/JCI2...
@jci.orgTSC1/2 mutations define an aggressive subtype of liver cancer.
Here, Zhang et al. find loss of hepatic TSC1 leads to noncanonical TFEB activation and promotes hepatocyte plasticity & tumor heterogeneity associated with high-grade malignancy in mouse and human HCC: doi.org/10.1172/JCI2...
@jci.orgSunday Readđź’«: What can 3,839,400 sibling pairs tell us about autoimmune disease? Eriksson et al. @ki.se quantified genetic correlations across 22 autoimmune diseases, showing substantial cluster-specific genetic overlap that largely aligns
with affected tissue types: doi.org/10.1172/JCI2...
@jci.orgWeekend Spotlight💫: As part of JCI’s review series on emerging therapeutic strategies in breast cancer, Fanucci et al. present: Toward targeted therapeutics for lobular breast cancer: doi.org/10.1172/JCI2...
stoverlab.bsky.social
@jci.orgA vasopressin gate transforms social distress into caregiving: doi.org/10.1172/JCI2...
Jonathan P. Fadok comments on Geng et al.: doi.org/10.1172/JCI2...
@jci.orgHypothalamic-amygdala-VTA circuit reinforces caregiving-like behavior doi.org/10.1172/JCI2...
Geng et al. show that vasopressin secretion initiates a positive feedback loop to promote grooming of an injured mouse, transforming distress into a prosocial response.
@jci.orgBehind the Paper: Wen Luo (corresponding author, rt) & Huijuan Wang (1st author, lft) capture images of embryonic hearts (1/2); and Huijuan Wang (1st author, lft) & Haosheng Zhang (co‑1st author, rt) isolate mouse embryonic heart tissues (2/2) iat the Institute of Modern Biology, Nanjing University
@jci.orgHAND2 lends a hand in coronary artery formation: doi.org/10.1172/JCI2...
Wang et al. identify HAND2 as a key cardiac transcription factor that helps build coronary arteries, revealing potential therapeutic targets for congenital and ischemic heart disease.
@jci.orgAs part of JCI’s review series on emerging therapeutic strategies in breast cancer, Kay et al. @petermaccc.bsky.social present: Breast cancer immunogenicity as a spectrum: evolving concepts and therapeutic implications: doi.org/10.1172/JCI2...
@jci.orgc-KIT expands the tool kit for treating arteriovenous malformation: doi.org/10.1172/JCI2...
Ruilin Wu & Jason E. Fish provide a Commentary on companion articles, Gahn et al. (doi.org/10.1172/JCI1...) and and Drapé et al. (doi.org/10.1172/JCI1...).
#AVM #HHT #VascularBiology
@jci.orgWe’re excited to revisit the 2021 Albert Lasker Basic Medical Research Award: doi.org/10.1172/JCI1...
“My plan was to purify the rhodopsin from this Chlamydomonas creature, and I thought I could do it in a year. But it took me 15 years, actually.”—Peter Hegemann
@jci.org🏅 Congratulations to Karl Deisseroth, Peter Hegemann, and Georg Nagel for the #NobelPrize in Physiology or Medicine 2026 on optogenetics!
@jci.orgSee the Commentary by Ruilin Wu & Jason E. Fish @FishLab_UHN, highlighting Gahn et al. and companion article, Drapé et al.: doi.org/10.1172/JCI2...
@jci.orgUnleashing c-KIT activates maladaptive vascular remodeling in HHT doi.org/10.1172/JCI1...
Gahn et al. show that SMAD4 limits c-KIT expression in endothelial cells. In a SMAD4-deficient HHT model, c-KIT derepression dysregulated mechanosensory-driven vascular remodeling.
@jci.orgSee the Commentary by Ruilin Wu & Jason E. Fish, highlighting Drapé et al. and the companion article Gahn et al.: doi.org/10.1172/JCI2...
@jci.orgAbnormal role of c-KIT in vascular endothelium drives brain AVMs
doi.org/10.1172/JCI1...
Drapé et al. show that pro-angiogenic c-KIT+ endothelial states induce brain arteriovenous malformations in an ALK1-deficient model of hereditary hemorrhagic telangiectasia.
@jci.orgViewpoint: Small populations, big impact: Leveraging rare disease gene therapies to benefit millions: doi.org/10.1172/JCI2...
Stephanie Cherqui discusses discoveries in rare disease research that have changed therapeutic principles for other diseases.
@jci.orgAs part of JCI’s review series on emerging therapeutic strategies in breast cancer, Chenxu Guo & Leif W. Ellisen present: Antibody-drug conjugates in #BreastCancer: redefining targeted therapy: doi.org/10.1172/JCI2...
@jci.orgWhy a positive rheumatoid factor test does not always mean rheumatoid arthritis: doi.org/10.1172/JCI2...
Luc Van Kaer comments on Hocaoglu and Sawalha: doi.org/10.1172/JCI2...
