Patricia Donnellan, MPH 🇺🇦📎

@stpaulsbay.bsky.social

Patricia Donnellan, MPH | Found the unifying cause of chronic disease: rs5522-driven inflammation. Cured my own 29-yr CFS. Proving it’s fluid, not fat—from Long COVID to Maternal Mortality. 🧬

www.beyondbloodtests.org

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We are going to rebuild the USA as a city upon a hill—one known for our values, not our weapons. A new dawn for humanity where we are not stuck in reactivity, not suffering from chronic inflammatory diseases we’ve been capable of preventing for more than half a century.

A better world. #rs5522

beyondbloodtests.orgBeyond Blood Tests | Enhance Your Health TodayExplore evidence-based health solutions beyond blood tests. Discover comprehensive health insights to support your wellness journey.
@stpaulsbay.bsky.social

The mechanism comes down to an intracellular cortisol deficit driven by a common genetic variant #rs5522, a blind spot that standard circulating lab panels cannot detect. Our published BBRC study outlines the molecular data.
The full breakdown of this genetic framework is available here. #LongCovid

@stpaulsbay.bsky.social

After living with an #ME/CFS diagnosis for 28 years, I have experienced a sustained, complete recovery for nearly a year. The intervention that resolved my symptoms wasn’t a novel pharmaceutical, but a safe, low-cost generic medication that has been widely available since 1960.

@abdulelsayed.bsky.socialReposted by @stpaulsbay.bsky.social

Blue Cross Blue Shield is being sued as a monopoly after the state found it's been in a conspiracy to restrict access to healthcare. Corporations should not have this much power. We need money out of politics, money in our pockets, and Medicare for All.

freep.comMichigan attorney general sues Blue Cross, alleging illegal monopolyMichigan Attorney General Dana Nessel sued Blue Cross Blue Shield of Michigan in "arguably the most consequential antitrust case" of its kind.
@stpaulsbay.bsky.social

I don't know if anyone will ever realize how hard I fought to save people from a physical prison. I found the mechanism & recovery path for #MECFS, now in a peer-reviewed journal. Patients contact me saying they are better, yet it feels like yelling into a void. Please help amplify. 🧬💙 #pwME #rs5522

@stpaulsbay.bsky.social

An immunologist will instantly understand how vital cortisol is as the body's primary anti-inflammatory brake. If it is being stolen inside the cell by an overactive, high-affinity MR before it can reach the GR to do its work, they will grasp the implications immediately. 🧬🔋

@stpaulsbay.bsky.social

The molecular mechanism is fully proven—our 2026 BBRC paper established the high-affinity MR cortisol steal past the cell wall using functional in vitro assays. The downstream application to #MECFS is the translational framework currently being replicated by patients who are improving.

@stpaulsbay.bsky.social

The immunology connection of #rs5522 is a failure of glucocorticoid-mediated immune resolution. The overactive, high-affinity MR sequesters intracellular cortisol starving the GR pathways needed to turn on the cell's master anti-inflammatory switch. Invisible to standard lab cortisol panels.

@stpaulsbay.bsky.social

Researchers point to a "unifying theory" of chronic fatigue/disease, mapping shared disturbed biological networks across #MECFS, Long COVID, MS, & RA.
But they miss the root cause. This network crash is driven by #rs5522 overactive MR receptors stealing the cortisol needed to fuel cells. 🧬🔋

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