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@unc-cbp.bsky.social Sep 17, 2026, 4:29 PM

Cover feature in Science Signaling: The Kathleen Caron Lab identified MYO6 as a regulator of signaling in lymphatic cells, revealing a previously unknown mechanism controlling lymphatic endothelial cell signaling and behavior.

doi.org/10.1126/scis...

@science.org

#Lymphatics #GPCR #UNCResearch

A published cover image in Science Signaling featuring a study by Serafin et al. The study shows that the motor protein MYO6 associates with a complex containing the protein RAMP3 and the G protein–coupled receptor CLR, which together function as a receptor for the peptide adrenomedullin (AM). MYO6 facilitated the internalization and endosomal signaling of RAMP3-CLR in response to AM in human lymphatic endothelial cells. The image is a light micrograph of a lymph vessel.
Credit: M. I. Walker/Science Source

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