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@philoneurosci.bsky.socialOct 1, 2026, 7:27 PM

#GPCR antagonism via rewiring of #receptor trafficking and degradation
doi.org/10.1038/s415...

@diabetologiajnl.bsky.socialSep 25, 2026, 12:34 PM

GPCRvp, a GPCR-specific variant impact predictor, decodes GLP1R missense variants using molecular dynamics + AI. It sharply reduces false positives vs AlphaMissense and improves prediction of GLP 1 drug response. #GLP1R #GPCR #Diabetes #Obesity link.springer.com/article/10.1... 🔓

@unc-cbp.bsky.socialSep 17, 2026, 4:29 PM

Cover feature in Science Signaling: The Kathleen Caron Lab identified MYO6 as a regulator of signaling in lymphatic cells, revealing a previously unknown mechanism controlling lymphatic endothelial cell signaling and behavior.

doi.org/10.1126/scis...

@science.org

#Lymphatics #GPCR #UNCResearch

A published cover image in Science Signaling featuring a study by Serafin et al. The study shows that the motor protein MYO6 associates with a complex containing the protein RAMP3 and the G protein–coupled receptor CLR, which together function as a receptor for the peptide adrenomedullin (AM). MYO6 facilitated the internalization and endosomal signaling of RAMP3-CLR in response to AM in human lymphatic endothelial cells. The image is a light micrograph of a lymph vessel. Credit: M. I. Walker/Science Source
@freegardener.bsky.socialSep 12, 2026, 10:22 AM

Structure beats sequence: AlphaFold2 reveals "superdark" GPCR-like proteins hiding in the dark proteome. TM184C links GPCR signaling #Proteomics #AlphaFold #GPCR #DarkProteome

https://freegardner.com/sci_scout/structure-reveals-hidden-gpcr-like-proteins-in-dark-proteome.html