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@sigtrans-sttt.bsky.socialOct 11, 2026, 12:30 PM

To overcome tumor immune evasion, researchers engineered NK cells that target PD-L1, block NKG2A/HLA-E inhibitory signaling, and produce IL15 to improve antitumor activity, survival, and metabolic fitness.

#OpenAccess: doi.org/10.1038/s413...
#TumorImmunology #CellTherapy #ImmunoOncology

@tenuretracker.bsky.socialOct 10, 2026, 12:04 PM

Linkoping University (@liu.se) is hiring:
Postdoc in Tumor Immunology and Immunotherapy

#postdoc #medicine #tumorimmunology

@tenuretracker.bsky.socialOct 2, 2026, 3:52 PM

Technische Universitat Munchen (@tum.de) is hiring:
PhD position in Tumor Immunology

#phd #medicine #tumorimmunology

@biomedicines.bsky.socialSep 30, 2026, 12:56 AM

🔬 Meet Associate Prof. Allan Stensballe, Chair for S1: Immune System, Tumor Immunology and Autoimmune Disease at #ECB2027!
📅 10–12 May 2027 | Online
📣 Abstract deadline: 15 Jan 2027
📝 FREE registration: 5 May 2027
🔗 sciforum.net/event/ECB2027 #TumorImmunology

@jem.orgSep 15, 2026, 1:45 PM

TNFR1 expression on cancer cells mediates immune escape and an immunosuppressive microenvironment. New study from Elixabet Bolaños, Ignacio Melero @unav.edu and colleagues:
rupress.org/jem/article/...

#TumorImmunology

@alicefrolov.bsky.socialSep 12, 2026, 5:18 PM

Sharing a new data visualization exploring the phenotypic reprogramming of exhausted CD8+ T cells following PD-1 axis blockade.

#TcellExhaustion #CheckpointBlockade #TumorImmunology #CD8Tcells #AntiPD1 #Tpex #ImmuneCheckpoint #CancerImmunotherapy

Sharing a new data visualization exploring the phenotypic reprogramming of exhausted CD8+ T cells following PD-1 axis blockade. Figure: "Reprogramming exhausted CD8+ T cells with anti-PD-1 therapy" Subtitle: "Marker-defined transitions from terminal exhaustion toward progenitor/effector states after checkpoint blockade" The visualization employs a faceted marginal-distribution slope arrow design, functioning as a state-transition flow map. Each facet corresponds to a defined exhaustion-associated marker axis (TCF1, TOX, TIM-3, PD-1, GZMB, and Ki-67), with paired marginal distributions rendered pre- and post-treatment. Slope arrows connect the density centroids across conditions, encoding both the directionality and relative magnitude of population-level marker shifts. This approach was chosen to make explicit the differential mobilization of progenitor-exhausted (Tpex) versus terminally exhausted (Tex_term) subsets rather than collapsing the transition into a single trajectory summary. The simulated data are calibrated to reproduce trends consistent with the current literature. Under anti-PD-1, the TCF1+ TOX-intermediate progenitor compartment shows expansion accompanied by upward slope vectors in Ki-67 and GZMB, consistent with proliferative burst and reacquisition of effector potential. Concurrently, the TIM-3-high, TCF1-negative terminally differentiated fraction contracts, and its centroid displays limited displacement along the TCF1 axis, reflecting the constrained plasticity of terminally exhausted cells. This asymmetry underscores that checkpoint blockade preferentially acts on the Tpex reservoir rather than fully reverting terminal exhaustion, a distinction with direct implications for durability of response.
@sigtrans-sttt.bsky.socialSep 9, 2026, 1:02 PM

How can #Cancer #Vaccines generate stronger immunity?

Protein condensate nanoadjuvants enhance antigen cross-presentation and activate DCs via mtDNA leakage-driven cGAS–STING signalling, promoting CD8⁺ T-cell antitumour responses.

#STTT #OpenAccess: doi.org/10.1038/s413...
#TumorImmunology

@rupress.orgSep 8, 2026, 4:45 PM

In @jem.org, Bolaños, Melero et al. @unav.edu show that tumor necrosis factor sensing by cancer cells through TNFR1 sets in motion forms of immunosuppressive protumor #inflammation that mediate escape from immune surveillance against tumors. rupress.org/jem/article/...

#TumorImmunology

@jem.orgSep 8, 2026, 4:00 PM

Bolaños, Melero et al. @unav.edu show that tumor necrosis factor sensing by cancer cells through TNFR1 sets in motion forms of immunosuppressive protumor #inflammation that mediate escape from immune surveillance against tumors. rupress.org/jem/article/...

#TumorImmunology