Merad, Yu, and Lichterfeld @ragoninstitute.bsky.social review how viral and host mechanisms let #HIV-1 reservoir cells persist for decades under ART, challenging classical latency models and arguing their immunological vulnerabilities can be exploited for cure strategies. rupress.org/jem/article/...

New JEM study @mengzelyu.bsky.social & Sonnenberg (doi.org/10.1084/jem....) reports a counterintuitive result: blocking B7 costimulation promotes, rather than suppresses, the microbiota-specific RORγt⁺ Foxp3⁺ Treg cells. From @cytokinesociety.bsky.social: signals.cytokinesociety.org/2026/10/06/l...

The IKKε-GABPA axis regulates STING transcription to orchestrate antiviral immunity and #inflammation. New from Jiaojiao Zhang, Tian Zhao, Hong Lei, Rui Gan, Guo Chen, Yanjun Li, Tong Yang, Xianwen Ren, and Yushan Zhu (Nankai University, Tianjin) et al.:
rupress.org/jem/article/...

#Lupus #SLE

Helios is critical for Treg effector differentiation in #adipose #autoimmunity. New study from Angela M. Thornton, Ethan M. Shevach and colleagues @niaidnews.bsky.social:
rupress.org/jem/article/...

#LymphocyteBiology #Tregs

Moussavi-Harami, Tartaglia, Lowell, Chan et al. report that biallelic loss-of-function variants in PTPN6, encoding the immune-regulatory phosphatase SHP1, cause #anemia and fatal lung #hyperinflammation in families from diverse ethnic backgrounds. rupress.org/jem/article/...

#Autoimmunity

📢 Calling #gradstudents, and early-career #postdocs! Apply for the JEM Early Career Travel Award ✈️ that supports your attendance at the #VIB #Neuroimmunology Conference @vibtrainconf.bsky.social (Nov. 19-20) in Antwerp!
Deadline ⏰ October 16, 2026
Apply here 👉 rupress.org/jem/pages/ea...

Reposts appreciated! Natural microbiota-based mouse models - particularly Wildlings - improve reproducibility & translation across a remarkable range of biomedical fields. Our new @jem.org Found in Translation! Thanks Isabel, Mario & @jonatcoquet.bsky.social! doi.org/10.1084/jem....

Gößwein, Ulmert, @srosshart.bsky.social, and @jonatcoquet.bsky.social describe how colonizing laboratory mice with a naturally evolved #microbiota can restore important features of mammalian physiology & how this can benefit translational research. rupress.org/jem/article/...

#FoundInTranslation

Our October issue is here! rupress.org/jem/issue/22...
The cover shows Sirius red staining in aged gastrocnemius muscle treated with UA-30 and injected with AAV-RalA (G23V) virus.
Zhang et al. describe the novel compound UA-30, which has anti-aging properties in muscle. doi.org/10.1084/jem....

#Autoantibodies neutralizing type I IFNs underlie ~5% of herpes simplex encephalitis in adults. By Julie Jensen, Morten Kelder Skouboe, Adrian Gervais, Shen-Ying Zhang, Søren Paludan, Aurelie Cobat, Jean-Laurent Casanova, Trine Mogensen @au.dk and colleagues: rupress.org/jem/article/...

CAMKV kinase drives #neuroblastoma growth and acts as a novel therapeutic target. New study from Yang Yu, Yanling Zhao, Zhongcheng Shi, Larry L. Wang, Chunchao Zhang, Jianhua Yang @childrensnational.bsky.social and colleagues:
rupress.org/jem/article/...

#SolidTumors

Slow-cooked naïve #Tcells make better effectors. Hee Yeun Won and Jung-Hyun Park (National Cancer Institute) discuss new study from Yamato Sajiki, Koichi Araki et al. @arakilab.bsky.social (rupress.org/jem/article/...) in Insights: rupress.org/jem/article/...

Vagal neuroimmune circuits in #inflammation and #immunity. New review from Tomás S. Huerta, Kevin J. Tracey, Isaac M. Chiu (@harvardmed.bsky.social), & Eric H. Chang (@northwellhealth.bsky.social):
rupress.org/jem/article/...

#Neuroscience #Neuroimmunology #BioelectronicMedicine #Neuroinflammation

Read Dr. Melero and colleagues’ JEM study: TNFR1 expression on cancer cells mediates immune escape and an immunosuppressive microenvironment. hubs.la/Q04wZjm20

“We are very proud of our JEM article and feel that it will receive wide exposure in the community.” — Ignacio Melero, Universidad de Navarra @unav.edu.

👉 Learn more about submitting to a journal valued by the community for its impact and integrity. hubs.la/Q04wZhXq0

Jiaojiao Zhang, Tian Zhao, Hong Lei, Rui Gan et al. identify the transcription factor GABPA as a critical regulator of STING expression, pivotal for antiviral defense and inflammatory diseases. rupress.org/jem/article/...

#InnateImmunity #inflammation #Lupus #SLE

Thornton, Shevach et al. demonstrate that in #Tregs, the transcription factor Helios directly controls Tcf1, Lef1, Id3, and Bach2 to regulate effector Treg generation and terminal differentiation. Mice with Helios-deficient Tregs show #adipose -specific #autoimmunity. rupress.org/jem/article/...

What’s a Journal-Based #CME activity? A full-text article that is free to read, a multiple-choice question test, and an evaluation/self-assessment. Our latest CME activity in collaboration with @mskcme.bsky.social is NOW available 👉 mskcc.cloud-cme.com/course/cours...

📢 Tell your friends and colleagues about JEM’s Early Career Travel Award! ✈️ 🧳 We're providing support for #gradstudents and early-career #postdoc researchers to attend the #VIB #Neuroimmunology Conference @vibtrainconf.bsky.social in Antwerp!
Apply here 👉 rupress.org/jem/pages/ea...