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@plosbiology.orgSep 17, 2026, 7:55 AM

R1-32-like public #antibodies drive #SARSCoV2 #virus to acquire #SpikeProtein mutations that promote #immune escape. This study characterises 4 such antibodies, showing that they acquire tolerance to SARS-CoV-2 antigenic drift via somatic hypermutation @plosbiology.org 🧪 buff.ly/iy4qUOe

Structures of mutation-tolerant antibodies in complex with SARS-CoV-2 BA.4/5 S-trimer and ACE2. Top: Cryo-EM densities of BA.4/5 S-R/6P S-trimer bound to Fab and ACE2 at 3:3:3 molar ratio. C092, C807, BD56-104, and BD56-597 Fabs, NTD, RBD, and ACE2 are colored in magenta, blue, cyan, and dark green, respectively; the rest of the S-trimer is colored in gray. The 3 RBDs in “up” positions are indicated, each simultaneously engaging both ACE2 and antibody. Bottom: Cryo-EM densities of BA.4/5 S1 bound to Fab and ACE2. C092, C807, BD56-104, and BD56-597 Fab-HC, Fab-LC, NTD, RBD, and ACE2 are colored in magenta, purple, blue, cyan, and dark green, respectively; the rest of the S1 is colored in gray.
@plosbiology.orgSep 16, 2026, 4:25 PM

R1-32-like public #antibodies drive #SARSCoV2 #virus to acquire #SpikeProtein mutations that promote #immune escape. This study characterises four such antibodies, showing that they acquire tolerance to SARS-CoV-2 antigenic drift via somatic hypermutation @plosbiology.org 🧪 buff.ly/iy4qUOe

Structures of mutation-tolerant antibodies in complex with SARS-CoV-2 BA.4/5 S-trimer and ACE2. Top: Cryo-EM densities of BA.4/5 S-R/6P S-trimer bound to Fab and ACE2 at 3:3:3 molar ratio. C092, C807, BD56-104, and BD56-597 Fabs, NTD, RBD, and ACE2 are colored in magenta, blue, cyan, and dark green, respectively; the rest of the S-trimer is colored in gray. The 3 RBDs in “up” positions are indicated, each simultaneously engaging both ACE2 and antibody. Bottom: Cryo-EM densities of BA.4/5 S1 bound to Fab and ACE2. C092, C807, BD56-104, and BD56-597 Fab-HC, Fab-LC, NTD, RBD, and ACE2 are colored in magenta, purple, blue, cyan, and dark green, respectively; the rest of the S1 is colored in gray.
@plosbiology.orgSep 16, 2026, 12:47 PM

R1-32-like public #antibodies drive #SARSCoV2 #virus to acquire #SpikeProtein mutations that promote #immune escape. This study characterises four such antibodies, showing that they acquire tolerance to SARS-CoV-2 antigenic drift via somatic hypermutation @plosbiology.org 🧪 plos.io/3TcJrFA

Structures of mutation-tolerant antibodies in complex with SARS-CoV-2 BA.4/5 S-trimer and ACE2. Top: Cryo-EM densities of BA.4/5 S-R/6P S-trimer bound to Fab and ACE2 at 3:3:3 molar ratio. C092, C807, BD56-104, and BD56-597 Fabs, NTD, RBD, and ACE2 are colored in magenta, blue, cyan, and dark green, respectively; the rest of the S-trimer is colored in gray. The 3 RBDs in “up” positions are indicated, each simultaneously engaging both ACE2 and antibody. Bottom: Cryo-EM densities of BA.4/5 S1 bound to Fab and ACE2. C092, C807, BD56-104, and BD56-597 Fab-HC, Fab-LC, NTD, RBD, and ACE2 are colored in magenta, purple, blue, cyan, and dark green, respectively; the rest of the S1 is colored in gray.
@sirhendrick.bsky.socialSep 14, 2026, 7:19 PM

Naomi Wolf tells us about what Pfizer knew about the effect on pregnancy. It's quite a lot. And Pfizer chose not to disclose it.
You decide what to think of this.
đź’‰ #Pfizer #vaccine #spikeprotein #pregnancy #fertility #infection #mRNA
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