In sum, #tissues tune #macrophage_numbers to their #mitochondrial_activity through a #CSF1 + #fibroblast niche, matching waste-clearance capacity to metabolic demand. This immune-metabolic coupling is essential to preserve mitochondrial fitness and tissue function

These observations raised an intriguing question: is #mitochondrial_activity directly linked🔗 to #clearance_demand❓ Our first clue was striking: across tissues, mitochondrial activity was directly proportional to the number of macrophages capturing parenchymal material ↗️

Thrilled to share our latest work, out in @sciimmunology.bsky.social ! We show that tissues match their #macrophage numbers to #mitochondrial_activity , ensuring efficient #waste_clearance and #tissue_fitness . A tour de force by Laura Pena-Couso, in collab with @drusqui.bsky.social & Pura Muñoz🧵