New US patent covers fibroblast-based treatment for wounds that won’t close – increasingly common, and risky, with age.

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#longevity #geroscience #fibroblast #wounds #aging

In sum, #tissues tune #macrophage_numbers to their #mitochondrial_activity through a #CSF1 + #fibroblast niche, matching waste-clearance capacity to metabolic demand. This immune-metabolic coupling is essential to preserve mitochondrial fitness and tissue function