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@sigtrans-sttt.bsky.socialSep 16, 2026, 3:00 AM

BCL9 drives the MerTK–ERK–SPP1 macrophage M2 program in #PulmonaryFibrosis, while its inhibition reprograms macrophage–fibroblast crosstalk toward fibroblast #Lipogenesis, supports AT2 cell expansion and attenuates #Fibrosis.

#STTT #OpenAccess: doi.org/10.1038/s413...

BCL9 inhibition promotes fibroblast lipogenesis by regulating macrophage–fibroblast interactions to attenuate pulmonary fibrosis
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