@sigtrans-sttt.bsky.social#Exosome heterogeneity may shape chronic lung allograft dysfunction.
An integrated single-vesicle #Multiomic atlas identifies distinct graft exosome populations and links an Ilk-high subset to pleural thickening in chronic rejection.
@genesndiseases.bsky.socialWhat if #noncodingRNAs encode disease-driving proteins?
This review highlights #exosome-derived ncRNA peptides as promising #biomarkers, therapeutic targets, and next-generation treatments across multiple diseases.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...
@cancers-mdpi.bsky.social🗞️Editor's Choice!
#ExtracellularVesicle-Mediated Delivery of #Curcumin Suppresses Tumor Progression in Murine Oral Squamous Cell Carcinoma
✏️by Nils Ludwig, Carolin Feldmann, Silvia Spoerl and Saigopalakrishna S. Yerneni
Link🔗 www.mdpi.com/2072-6694/18...
#ECV #exosome #OSCC
![Figure 1. Characterization of JsEV and curcumin-loaded JCsEV. (A) Particle size distribution and concentration profiles of JsEV and JCsEV determined by nanoparticle tracking analysis (NTA). Representative measurements demonstrate a predominant vesicle population within the expected size range of sEVs. (B) Representative transmission electron microscopy (TEM) images of JsEV and JCsEV showing typical cup-shaped vesicles with heterogeneous size distribution. Scale bars: 200 nm. (C) Western blot analysis of JsEV and JCsEV demonstrating the presence of canonical sEV markers (TSG101 and CD9) and the absence of the negative marker GRP94. Each lane was loaded with 5 µg protein. Curcumin loading was performed using a previously HPLC-validated protocol demonstrating a loading efficiency of 0.56 ± 0.01 µg curcumin per 1 µg albumin-EV [19].](https://cdn.bsky.app/img/feed_fullsize/plain/did:plc:gtwq6vtyyymmu7vxtnu2ujmq/bafkreidd6to3zoebrj54yzdocfx4ktwczgplhij4kh2ksnnzhq3qvvuvo4@jpeg)