#BiodiversityLoss
#Extinction
#OceanHeat
#ExtremeHeat
#RecordHeat
#RateOfChange
#AquaticDeoxygenation
#FreshWaterSystems
#MarineSystems
#Acidification
#Hypoxia
#DeadZones
#SoilBiome
#Ecosystems
#FoodChains
#PlanetaryBoundaries
#Oil
#Coal
#Gas
#FossilFuelPollution
#AnthropogenicGlobalWarming

#Oscillations
#ENSO
#ElNiño
#OceanHeat
#ExtremeHeat
#RecordHeat
#Drought
#Fire
#Precipitation
#ExtremePrecipitation
#ExtremeWeather
#Acidification
#Hypoxia
#BiodiversityLoss
#Extinction
#Food
#ThermalExpansion
#SeaLevelRise
#Oil
#Coal
#Gas
#FossilFuelPollution
#AnthropogenicGlobalWarming

Repeated hypobaric #hypoxia triggers distinct metabolic responses: muscle LDH activity mirrors plasma lactate levels, whereas liver LDH activity aligns with glucose maintenance. #Physiology #medsky
#BIOI #OpenAccess: doi.org/10.15212/bio...

#Hypoxia makes liver cancer harder to treat.

This study shows that 3-BrPA enhances arterial #embolization, suppressing tumor growth and promoting necrosis, offering a strategy to overcome hypoxic resistance.
#currentmedicalscience: doi.org/10.1007/s115...

#HepatocellularCarcinoma #LiverCancer

#Oscillations
#ENSO
#ElNiño
#OceanHeat
#ExtremeHeat
#RecordHeat
#Drought
#Fire
#Precipitation
#ExtremeWeather
#Acidification
#Hypoxia
#CoralReefs
#BiodiversityLoss
#Extinction
#Food
#ThermalExpansion
#SeaLevelRise
#HumanDisplacement
#Oil
#Coal
#Gas
#FossilFuelPollution
#AnthropogenicGlobalWarming

15. Harnessing transcriptional regulation of alternative end-joining to predict cancer treatment - Espín et al. doi.org/10.1093/narc... Links #hypoxia/HIF1α and #MYC to #PARP1/POLQ expression and alternative end joining, with combination-treatment effects in cancer cells. 16/18

Chemical #priming of #hypoxia responses via PLANT #CYSTEINE OXIDASE inhibition improves #flooding tolerance

academic.oup.com/plphys/artic...

#PlantScience @plantphys.bsky.social @aspbofficial.bsky.social @planteditors.bsky.social @isplore.bsky.social @plant-sci.bsky.social @sciplant.bsky.social

Study of #hemoglobin mass and #plasma volume regulation in adults from six Andean regions at different altitudes reports #hemoconcentration and #erythropoiesis contribute equally to increased [Hb] at moderate #altitude.

doi.org/10.14814/phy...
#Hypoxia

marine.copernicus.eu/news/publica...

#OceanHeat
#MarineHeatWaves
#Acidification
#Hypoxia
#DeadZones
#CoralReefs
#TippingPoints
#HabitatLoss
#FoodChains
#BiodiversityLoss
#Extinction
#Food

#OceanHeat
#EarthsEnergyImbalance
#EquilibriumClimateSensitivity
#ExtremeHeat
#RecordHeat
#MarineHeatWaves
#Acidification
#Hypoxia
#DeadZones
#CoralReefs
#TippingPoints
#HabitatLoss
#FoodChains
#BiodiversityLoss
#Extinction
#Food
#Oil
#Coal
#Gas
#FossilFuelPollution
#AnthropogenicGlobalWarming

#Oscillations
#ENSO
#ElNiño
#OceanHeat
#ExtremeHeat
#Drought
#Fire
#Precipitation
#ExtremeWeather
#Acidification
#Hypoxia
#CoralReefs
#TippingPoints
#BiodiversityLoss
#Extinction
#Food
#ThermalExpansion
#SeaLevelRise
#HumanDisplacement
#Oil
#Coal
#Gas
#FossilFuelPollution
#AnthropogenicGlobalWarming

sp.copernicus.org/articles/7-o...

#OceanHeat
#EarthsEnergyImbalance
#EquilibriumClimateSensitivity
#ExtremeHeat
#RecordHeat
#Acidification
#Hypoxia
#DeadZones
#CoralReefs
#HabitatLoss
#FoodChains
#BiodiversityLoss
#Extinction
#Food
#Oil
#Coal
#Gas
#FossilFuelPollution
#AnthropogenicGlobalWarming

#Oscillations
#ENSO
#ElNiño
#OceanHeat
#ExtremeHeat
#Drought
#Fire
#Precipitation
#ExtremeWeather
#Acidification
#Hypoxia
#CoralReefs
#TippingPoints
#BiodiversityLoss
#Extinction
#Food
#ThermalExpansion
#SeaLevelRise
#HumanDisplacement
#Oil
#Coal
#Gas
#FossilFuelPollution
#AnthropogenicGlobalWarming

Carbonic anhydrase 9, an intracellular pH regulator, is widely used to mark #Hypoxia in tumors (+some tissues)

Here's new evidence for CA9 (+CA12) in human pulmonary arterial #SmoothMuscleCell & 🐭#PulmonaryHypertension (S4, CA9/CA12 dual inhibitor) 😎

#AJRCMB 2026
academic.oup.com/ajrcmb/advan...

🎯 Non-toxic #multidrug combos for RCC—rationally designed, hypoxia-enhanced. ODCs show up to 77% efficacy in 2D & 62% in 3D spheroids. Durable responses, no toxicity in organ models.

📌 doi.org/10.3390/phar...
#RCC #DrugCombinations #Hypoxia #CancerTherapy

Artificial downwelling for mitigating marine #hypoxia: a review of biogeochemical responses, ecological effects, and adaptive optimization strategies link.springer.com/article/10.1...

How do cells rewire fat metabolism when oxygen runs low? At #HypoxEU, @LozaValdes (@UniHeidelberg) showed losing the E3 ligase RNF145 helps cells survive hypoxia by storing fatty acids as triacylglycerol instead of toxic lipids. Great poster, Angel! #Hypoxia #LipidMetabolism

#Oscillations
#ENSO
#ElNiño
#OceanHeat
#ExtremeHeat
#Drought
#Fire
#Precipitation
#ExtremeWeather
#Acidification
#Hypoxia
#CoralReefs
#TippingPoints
#BiodiversityLoss
#Extinction
#Food
#ThermalExpansion
#SeaLevelRise
#HumanDisplacement
#Oil
#Coal
#Gas
#FossilFuelPollution
#AnthropogenicGlobalWarming

Beyond #hypoxia: Context-dependent #transcriptional reprogramming by #ERFVIIs

onlinelibrary.wiley.com/doi/10.1111/...

#PlantScience @jipb.bsky.social @wileylifesci.bsky.social @wileyecology.bsky.social @isplore.bsky.social @plant-sci.bsky.social @sciplant.bsky.social @plantresearch.bsky.social

#TherapeuticPotential of combining #IRE1α and #KRAS inhibition in #PancreaticDuctalAdenocarcinoma doi.org/10.1073/pnas... #PDAC #Hypoxia #Oncology #LiverCancer #SolidTumor #TranslationalScience