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@thelancetendo.bsky.socialSep 20, 2026, 11:55 AM

Large, rigorous randomised controlled trials of lifestyle, pharmacological, and surgical weight-loss strategies are therefore urgently needed to define potential disease-modifying effects www.thelancet.com/journals/lan...
#obesity
#disease-modifying therapies

#MedSky #EndoSky

@drjwdietrich.bsky.socialSep 20, 2026, 10:09 AM

🧪 🩺 #MedSky @medsky.social Endocrinology #Endosky

@thelancetendo.bsky.socialSep 20, 2026, 8:30 AM

Published in The Lancet Regional Health – Southeast Asia

#Iodine nutrition, #thyroid function, & thyroid #autoimmunity four decades after Universal Salt Iodisation in India: a cross-sectional study among schoolchildren (ICMR-SALT-T 1) www.thelancet.com/journals/lan...
#OpenAccess

#MedSky #EndoSky

@thelancetendo.bsky.socialSep 19, 2026, 12:59 PM

Despite advances in #hypoparathyroidism management, important unmet needs remain, including earlier identification of genetic forms and improved therapies to reduce complications and optimise quality of life (QoL) www.thelancet.com/journals/lan...
#hypocalcaemia #hyperphosphataemia #PTH

#EndoSky

@thelancetendo.bsky.socialSep 19, 2026, 12:42 PM

This TimeCapsule reviews the major transformations in #lipid #metabolism & #cardiovascular #disease #prevention during the first quarter of the 21st century & their impact on clinical practice thelancet.com/journals/lan...
#LDL #cholesterol #ASCVD
#FREE to read w/reg (also FREE)

#EndoSky #cardioSky

@thelancetendo.bsky.socialSep 18, 2026, 9:21 AM

Over the past two or three decades, the demographics of type 1 #diabetes have shifted to include a greater proportion of #older #adults, reflecting a population comprising both individuals with youth-onset and adult-onset disease www.thelancet.com/journals/lan...
#olderadults #T1D

#MedSky #EndoSky

@endomedia.bsky.socialSep 17, 2026, 2:12 PM

Excited to listen to an all @endocrinesociety.bsky.social episode of @scifri.bsky.social on perimenopause featuring women's health experts President Dr. Nanette Santoro and Dr. Genevieve Neal-Perry! bit.ly/4xvyv4g #menopause #EndoSky

@thelancetendo.bsky.socialSep 17, 2026, 12:40 PM

#Male #hypogonadism caused by an intrinsic & often irreversible HPT pathology is called organic (also termed classical) hypogonadism. Organic hypogonadism has a straightforward, established diagnostic & treatment pathway www.thelancet.com/journals/lan...
#MensHealth
#MedSky #EndoSky #MensHealthSky

@thelancetendo.bsky.socialSep 17, 2026, 10:50 AM

The aberrant expression of diverse G-protein coupled receptors (GPCRs) & their ligands play an important role in the over-function of various endocrine tumours www.thelancet.com/journals/lan...
#cortisol-secreting primary bilateral macronodular #adrenal hyperplasia #unilateral #adenomas

#EndoSky

@thelancetendo.bsky.socialSep 17, 2026, 10:33 AM

#Endocrine #complications occur in 40–60% of #survivors of #cancer and include hypothalamic–pituitary disorders, dysregulation of steroid and peptide hormones, and dysregulation of bone and metabolism www.thelancet.com/journals/lan...
#OpenAccess

#MedSky #EndoSky #OncSky

@pulmonologyadvisor.bsky.socialSep 15, 2026, 3:53 PM

From @accpchest.bsky.social 🫁

Patients with #COPD and #T2DM showed lower lung cancer risk with #SGLT2Inhibitor initiation than with #sulfonylureas medications, particularly men and those with a history of smoking. #PulmSky #EndoSky

@natrevendo.nature.comSep 14, 2026, 3:58 PM

Here, this international Consensus Statement by Maria Fleseriu et al provides guidelines on the management of pituitary incidentalomas go.nature.com/4itSjB3 #EndoSky #MedSky

Figure showing an algorithm for assessment of an incidentally discovered pituitary adenoma on imaging managed conservatively.
@natrevendo.nature.comSep 14, 2026, 3:56 PM

In this article, Qiong A. Wang and colleagues outline the in endocrine and metabolic function that occur in various adipose tissue depots during ageing (£) go.nature.com/4gSSbdl #EndoSky #MedSky

Figure showing cellular alterations in WAT during the early stage of ageing.
@natrevendo.nature.comSep 14, 2026, 3:52 PM

Here, Francisca L. Henriques, Irina Buckle & Josephine M. Forbes review strategies for type 1 diabetes mellitus prevention (£) go.nature.com/4gT9Stf #EndoSky #MedSky

Figure showing a selection of therapeutic approaches in phase Ib–III clinical trials aiming to prevent ongoing β-cell damage and destruction during the development and progression of T1DM.
@natrevendo.nature.comSep 14, 2026, 3:47 PM

In this Review, Anne-Simone Parent et al discuss the potential effects of endocrine-disrupting chemicals in female reproductive health (£) bit.ly/4r8Lx5U #EndoSky #MedSky

Figure showing female reproductive development and functions susceptible to perturbation by endocrine-disrupting chemicals.
@thelancetendo.bsky.socialSep 14, 2026, 11:28 AM

#Hypertriglyceridaemia-induced acute
#pancreatitis is a complex inflammatory disease that
requires immediate medical attention and supportive
care www.thelancet.com/journals/lan...
#triglycerides

#MedSky #EndoSky #CardioSky #GastroSky

Intravenous insulin activates LPL, which increases the clearance of triglycerides from the circulation. Heparin binds to HSPG and releases LPL, leading to a reduction in plasma triglycerides. Heparin also reduces inflammation, oxidative stress, and protects mitochondria in acinar cells of the pancreas. These effects are independent of the triglyceride-lowering effect of heparin. Plasma exchange (plasmapheresis) removes triglycerides directly from circulation. HSPG=heparan sulphate proteoglycan. LPL=lipoprotein lipase.
@thelancetendo.bsky.socialSep 14, 2026, 11:23 AM

Despite advances, #familial #hypercholesterolaemia is still inadequately diagnosed and undertreated, with many affected people remaining at high risk of early #cardiovascular #disease www.thelancet.com/journals/lan...
#HeFH #HoFH #ASCVD #LDL #cholesterol

#MedSky #EndoSky #CardioSky

@thelancetendo.bsky.socialSep 14, 2026, 10:16 AM

Also watch the Video Abstract:

25 Years of Lipid Medicine www.youtube.com/watch?v=atCH...

#MedSky #EndoSky #CardioSky

@thelancetendo.bsky.socialSep 14, 2026, 10:16 AM

This TimeCapsule reviews the major transformations in #lipid #metabolism and #cardiovascular #disease #prevention during the first quarter of the 21st century and their impact on clinical practice www.thelancet.com/journals/lan...
#LDL #cholesterol #ASCVD
#FREE to read w/reg (also FREE)

#EndoSky

The upper and lower blue bands represent the principal concepts that have driven clinical practice. Along both sides of the timeline arrow are the acronyms of the main randomised controlled trials. Positive outcome trials are shown in black and negative ones in red. Grey squares indicate studies that led to changes in guidelines and conceptual frameworks. Negative trials that influenced guideline development are shown in orange. Non-trial studies are in italic font. At the base of the timeline arrow are studies that laid the foundation at the end of the 20th century. The upper right section highlights emerging developments, including new molecular targets and innovative lipid-lowering therapies. See the appendix (pp 1–6) for details on the studies. ANGPTL3=angiopoietin-like 3. PCSK9=proprotein convertase subtilisin/kexin type 9.
@thelancetendo.bsky.socialSep 13, 2026, 2:51 PM

Goal-directed #osteoporosis treatment: are bone mineral density targets valid? www.thelancet.com/journals/lan...
#BMD
#OpenAccess

#MedSky #EndoSky #RheumSky