What's next for #lipid-based #RNA #delivery? This review covers rational vs combinatorial design, multiplexed formulation, #protein corona principles, biophysical mechanisms & #machine #learning approaches.

👉 doi.org/10.3390/phar...
#RNADelivery #LipidNanoparticles #Formulation #Nanomedicine

Major transformations in #lipid #metabolism & #cardiovascular disease prevention have occurred during the first quarter of the 21st century & have impacted clinical practice. Find out more in this TimeCapsule article www.thelancet.com/journals/lan...
#LDL #cholesterol

#MedSky #EndoSky #CardioSky

📣 New Podcast! "EP- 324| HbA1c: Your 3-Month Sugar Report made simple explained: — ৩ মাসের Sugar Report সহজ ভাষায় | wellness podcast series" on @Spreaker #ala #bloodsugar #brain #dha #diabetics #fitness #hba1cs #health #healthylife #heart #jontrona #lipid #liver #nutrition #oil #omega3 #seed

Components of an #ESCRT-independent #NuclearEnvelope assembly pathway. New study from Emma M. Sydir, I-Ju Lee, David Pellman @danafarber.bsky.social @harvard.edu and colleagues:
rupress.org/jcb/article/...

#CellCycle #CellDivision #Genetics #Biochemistry #Membrane #lipid

Dr. Ben Lidgard discusses "Lipid Lowering in CKD: The Nephrologist's Role" in his Grand Rounds presentation @uwnephrology.bsky.social @uwdeptmedicine.bsky.social
#nephsky #kidney #CKD #Lipid #cholesterol

youtu.be/Qq5BXEbhF2k?...

📣 New Podcast! "EP- 322 |Diabetes Blood Report Made Simple — ডায়াবেটিসের রক্ত রিপোর্ট সহজ ভাষায়| Diabetic wellness series" on @Spreaker #bloodsugar #brain #cholesterol #diabetics #dietician #fasting #fitness #heart #joint #jontrona #kidney #lipid #liver #nerve #omega3 #rbc #superfood #test

📰 The molecular mechanism that regulates TMEM63B lipid scrambling

TMEM63B, a mechanosensitive lipid scramblase, has an autoinhibitory domain in its C-terminal tail that helps keep it inactive under...

Source: Phys.org | Read story

💬 What's your take on this tech shift?

#TechBluesky #Lipid #Keep

Sydir, Lee, Pellman et al. @harvard.edu @danafarber.bsky.social identify an #ESCRT-independent pathway for #NuclearEnvelope assembly in S. japonicus that involves the conserved proteins, Vid27 and Alx1. rupress.org/jcb/article/...

#CellCycle #CellDivision #Genetics #Biochemistry #Membrane #lipid

🏅 77 citations — #highly #cited! #Lipid #nanoparticles for #biologics—chemistry, manufacturing, characterization & scale-up. Covers #proteins, #nucleic #acids & #mRNA, plus opportunities & challenges.

⚗️ www.mdpi.com/1999-4923/16...
#LipidNanoparticles #Biologics #DrugDelivery

🤔 Can #oral insulin overcome GI degradation? This study uses #solid #lipid #nanoparticles from natural soaps via coacervation + hydrophobic ion pairing. Gut permeation enhanced; #spray-dried #powder enables solid forms!

📌 www.mdpi.com/1999-4923/17...
#OralInsulin #Nanoparticles #DrugDelivery

Human cellular models of the brain to study #lipid homeostasis in #AlzheimersDisease and related dementias

Sarah E. Heuer @heuerwego.bsky.social, Fasih M. Ahsan, Tracy L. Young-Pearse @typlab.bsky.social #ipscs

link.springer.com/article/10.1...

Characterization of male #Glyoxalase1 knockout mice demonstrates a role in #lipid #metabolism by the #liver, with minimal effects on #adipose or #kidney function.

doi.org/10.14814/phy...

@physoc.bsky.social
@apspublications.bsky.social
@wileylifesci.bsky.social

This TimeCapsule reviews the major transformations in #lipid #metabolism & #cardiovascular #disease #prevention during the first quarter of the 21st century & their impact on clinical practice thelancet.com/journals/lan...
#LDL #cholesterol #ASCVD
#FREE to read w/reg (also FREE)

#EndoSky #cardioSky

25 Years of #Lipid Medicine
youtube.com/watch?v=atCH...

#LDL #cholesterol #ASCVD #statins #PCSK9 inhibitors #ezetimibe #RNA-based drugs #gene editing

Dysfunction of #caveolae in muscle disease: a cell biological perspective. From Harriet P. Lo, Robert G. Parton and colleagues (The University of Queensland)
rupress.org/jcb/article/...

#Organelles #Development #Membrane #lipid #Disease #SkeletalMuscle

Our #Lipid & #Membrane collection highlights work on a novel acyl-CoA binding protein, and lipid organization at the soma–germline boundary in the #Drosophila embryo, and a review on detecting and modulating membrane lipids and a new toolset for #phospholipid monitoring 👉 rupress.org/jcb/collecti...

This TimeCapsule reviews the major transformations in #lipid #metabolism and #cardiovascular #disease #prevention during the first quarter of the 21st century and their impact on clinical practice www.thelancet.com/journals/lan...
#LDL #cholesterol #ASCVD
#FREE to read w/reg (also FREE)

#EndoSky

Mayor intensidad de la lactancia se asocia con un perfil cardiometabólico temprano más favorable en mujeres con diabetes gestacional previa #breastfeeding #lipid #gestationaldiabetes jamanetwork.com/journals/jam...

Lipid-mediated activation of BLT2 promotes membrane repair to prevent cell death. New study from Yuan Chi, Kazuko Saeki, Takehiko Yokomizo and colleagues (Juntendo University):
rupress.org/jcb/article/...

#Biochemistry #Membrane #lipid

🏅Editor's Choice #Review
#Lipid Metabolism Reprogramming in Diffuse Large B-Cell Lymphoma (#DLBCL): Mechanisms and Treatment Strategies
🧑‍🔬Yue-E Ding, Yi-Ran Zhong et al.
Unlock🔓 www.mdpi.com/2072-6694/18...
#lymphoma #metabolism #ImmuneMicroenvironment #ferroptosis