Divergent PML and Nucleolar Body Programs Distinguish Protected from Vulnerable Neurons in FTLD-TDP #SingleCell 🧪🧬🖥️
https://www.researchsquare.com/article/rs-11089898/latest

Baseline immune transcriptional signatures predict checkpoint blockade response in triple-negative breast cancer #SingleCell 🧪🧬🖥️
https://www.researchsquare.com/article/rs-11198657/latest

RNA splicing factor mutations drive myeloid neoplasm oncogenesis through protein complex poisoning #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.64898/2026.09.29.754980v1

Endothelial AMBRA1 loss contributes to vascular dysregulation facilitating metastatic progression in early-stage melanoma #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.64898/2026.09.29.755318v1

Dual inhibition of p38α MAPK and Casein kinase δ/ϵ as a novel treatment strategy for AR-independent and taxane-resistant advanced prostate cancer #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.64898/2026.09.29.754128v1

Spatially resolved transcriptomics of poplar reveals tissue organization across shoot-associated organs #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.64898/2026.09.29.754462v1

Epigenetics Update - A cross-species single-cell kidney epigenome atlas reveals epithelial-dominant aging-like states in disease www.nature.com/articles/s43...

Sanjay Jain and Kun Zhang (Altos Labs) in Nature Aging

#Epigenetics #Aging #Epigenome #SingleCell #Multiomics
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epigenometech.com

Inverse directions of association of higher physical activity and higher insulin resistance with human skeletal muscle fiber-type gene expression, Ciotlos et al.

snRNA-seq of skeletal muscle from 263 people
🧬 🖥️🧪 #snRNAseq #RNAseq #SingleNucleus #SingleCell
www.sciencedirect.com/science/arti...

September 30, 2026
👉 A discovery could open a new path to addressing a devastating complication of pancreatic cancer.
🙂 Another encouraging news from Groupe UIG.
Read: doi.org/10.1016/j.ce...
#GroupeUIG #Cancer #PancreaticCancer #Oncology #CellBiology #SingleCell

Single-cell transcriptomic prioritization of SQLE and functional validation of SQLE inhibition in colorectal cancer cells #SingleCell 🧪🧬🖥️
https://www.researchsquare.com/article/rs-10900017/latest

Gene flux shapes diversity and evolution of the ancient 17q21.31 inversion polymorphism #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.64898/2026.09.28.755014v1

Accurate and scalable demultiplexing of single-cell RNA sequencing using BEACON #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.64898/2026.09.26.754667v1

📃 In a new preprint, scientists introduce two standardized, end-to-end pipelines for single-cell RNA-seq and imaging-based #spatialtranscriptomics analysis.

EISCA supports droplet- and plate-based scRNA-seq, while EISTA is tailored for high-resolution spatial platforms.

#SingleCell #RNAseq

Weekly reads 21/09/26:
How tumors exploit cell states and how we're learning to engineer our own

behindthebioinformatics.substack.com/p/weekly-rea...

#CancerResearch #SingleCell #TumorMicroenvironment #SyntheticBiology

An Efficient Machine Learning Approach for Degradation Forecasting in AEM Water Electrolysis #SingleCell 🧪🧬🖥️
https://arxiv.org/abs/2609.37941

CancerZigZag: Iterative Seed-Anchored Diffusion for Generative Modeling of Single-Cell State Transitions #SingleCell 🧪🧬🖥️
https://arxiv.org/abs/2609.37735

Stochastic gradient descent on the epigenetic landscape: a unified framework for cellular plasticity, tumor heterogeneity, and the asymptotic irrelevance of fitness #SingleCell 🧪🧬🖥️
https://arxiv.org/abs/2609.37703

Gel-Confined Rolling-Circle Amplification Enables Sensitive Single-Cell Proteoform Analysis #SingleCell 🧪🧬🖥️
https://arxiv.org/abs/2609.36251

Mapping the response of primary human chondrocytes to an osteoarthritis-relevant stimulus by single-cell RNA sequencing #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.64898/2026.09.24.754148v1

Single-cell profiling resolves gain- and loss-of-function mechanisms in CASR to advance mechanism-aware variant classification #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.64898/2026.09.26.754690v1