@thelancetendo.bsky.socialDespite the availability of safe and effective therapies for #osteoporosis, these therapies are underused in individuals at high risk for #fracture, calling for better case-finding and fracture risk assessment strategies www.thelancet.com/journals/lan...
#AI #ML
@thelancetendo.bsky.socialAlthough #fracture risk is often lower in #osteopenic women than in those with #osteoporosis, their greater number means that most fractures occur in osteopenic individuals www.thelancet.com/journals/lan...
#osteopenia
@thelancetendo.bsky.social#Fractures affect a substantial proportion of people with #obesity and result from reduced #bone strength relative to increased mechanical loading, together with an increased risk of #falls www.thelancet.com/journals/lan...
#osteoporosis
@thelancetendo.bsky.social#Fragility #fractures remain a common & serious complication of long-term oral #glucocorticoid therapy that might affect all skeletal sites, although the spine is particularly prone to fractures owing to its high proportion of trabecular bone www.thelancet.com/journals/lan...
#OpenAccess
@thelancetendo.bsky.socialMost #diabetes guidelines focus on improving glycaemia through addition of medications, but few address strategies to reduce medication burden for older adults—a concept known as #deprescribing www.thelancet.com/journals/lan...
#T1D #T2D #olderadults
#FREE to read w/reg (also FREE)
#MedSky #EndoSky
@thelancetendo.bsky.social#Diabetes-related #foot #ulcers (DFUs) continue to inflict a harmful toll on people with diabetes due to the medical treatments and lifestyle changes needed to heal these lesions or, in the case of healing failure, limb loss through amputation www.thelancet.com/journals/lan...
@thelancetendo.bsky.socialCalcilytics (eg, encaleret) normalise calcium-sensing receptor (CaSR) hyperactivation in patients with autosomal dominant #hypocalcaemia type 1 and have the potential for broader application in other forms of #hypoparathyroidism thelancet.com/journals/lan...
#hypoparathyroidism
@thelancetendo.bsky.socialThe field of #obesity has markedly changed in recent years and obesity is increasingly regarded as a gateway disease towards the development of various conditions www.thelancet.com/journals/lan...
@thelancetendo.bsky.socialRobust trial evidence supports weight loss as a disease-modifying strategy in some conditions, including but not limited to type 2 #diabetes & #heartfailure with preserved ejection fraction www.thelancet.com/journals/lan...
#incretin-based therapies #weightloss #T2D
@thelancetendo.bsky.socialPublished in The Lancet Regional Health – Southeast Asia
Prevalence of and factors associated with gestational diabetes mellitus and diabetes in pregnancy in Bangladesh: a facility-based cross-sectional study (2019–2020) www.thelancet.com/journals/lan... #GDM
#OpenAccess
@thelancetendo.bsky.social#Ketoacidosis risk with #SGLT2 inhibitors varies greatly by patient characteristics and is not confined to early in treatment www.thelancet.com/journals/lan...
#DKA type 2 #diabetes #T2D
@thelancetendo.bsky.socialVideo Abstract—25 Years of Lipid Medicine youtube.com/watch?v=atCH...
#LDL #cholesterol #ASCVD #statins #PCSK9 inhibitors
#ezetimibe #RNA-based drugs #gene editing
@thelancetendo.bsky.socialFunctional #parathyroid cells derived from pluripotent #stem #cells, including embryonic and induced pluripotent stem cells, represent a potential curative approach for #hypoparathyroidism thelancet.com/journals/lan...
#stemcells
@endomedia.bsky.socialBreaking news: @endocrinesociety.bsky.social unveils Scientific Statement examining next steps as new medications transform obesity treatment. bit.ly/4xLuvgH @danieljdrucker.bsky.social #EndoSky
@thelancetendo.bsky.social#Prolactinomas are the most common pathological cause of #hyperprolactinaemia and represent approximately half of #pituitary #adenomas. Among patients aged 20–50 years, prolactinomas are ten times more common in women than in men www.thelancet.com/journals/lan...
#prolactin
@natrevendo.nature.comIn our October issue, Chuang Liu and colleagues present a Comment on mRNA-LNP therapeutics for obesity (£) go.nature.com/4h1syFT #EndoSky #MedSky
@natrevendo.nature.comFrom our October issue: Leonardo de Assis et al discuss the transition from postdoctoral researcher to independent investigator rdcu.be/pggtNCksJtHa #EndoSky #MedSky
@natrevendo.nature.comIn this Perspective, Soo Lim et al advocate for an approach to assessments for obesity in Asian populations that takes ethnicity-specific factors into account (£) go.nature.com/4dr6NhA #EndoSky #MedSky
@natrevendo.nature.comIn our latest issue: Christofer Juhlin and colleagues discuss how molecular alterations in thyroid cancer affect iodine uptake and describe redifferentiation strategies that aim to improve the effectiveness of radioiodine administration (£) go.nature.com/4qZ1Ty2 #EndoSky #MedSky
@natrevendo.nature.comIn our latest issue: Tony Lam and colleagues outline how lipid sensing triggers hormonal and neural mechanisms that regulate satiety and glucose homeostasis and how these pathways are affected by obesity and metabolic disease (£) go.nature.com/4yte0WF #EndoSky #MedSky
