Also read the original TimeCapsule article:
A quarter-century of progress: innovations in lipid medicine that transformed cardiovascular prevention thelancet.com/journals/lan...
#LDL #cholesterol #ASCVD #statins #PCSK9 inhibitors

#MedSky #EndoSky #CardioSky

25 Years of Lipid Medicine youtube.com/watch?v=atCH...
#LDL #cholesterol #ASCVD
#statins #PCSK9 inhibitors

#MedSky #EndoSky #CardioSky

25 Years of #Lipid Medicine
youtube.com/watch?v=atCH...

#LDL #cholesterol #ASCVD #statins #PCSK9 inhibitors #ezetimibe #RNA-based drugs #gene editing

Fudan University researchers developed #etBE, an engineered Transformer #BaseEditor with up to 35-fold higher C-to-T editing efficiency that achieved 35.13% in vivo liver editing and a 33% LDL-C reduction in mice without off-target trade-offs. 🧬🤖 #FudanUniversity #GeneTherapy #PCSK9

#ColumbiaUniversity researchers demonstrated that ABE8e-V106W RNP achieves 100% on-target editing in human embryos without #Cas9 -like double-strand breaks, but uncontained off-target editing, bystander mutations, and mosaicism render clinical reproductive use premature. 🧬🤖 #HumanEmbryo #PCSK9

📊 Among UK Biobank participants, lifelong genetic inhibition of #PCSK9 was associated with lower low-density lipoprotein cholesterol without increased liver enzyme levels or incident #ChronicLiverDisease. ja.ma/4yi3tNR

Video Abstract—25 Years of Lipid Medicine youtube.com/watch?v=atCH...
#LDL #cholesterol #ASCVD #statins #PCSK9 inhibitors
#ezetimibe #RNA-based drugs #gene editing

#MedSky #EndoSky #CardioSky

New Video Abstract:

25 Years of Lipid Medicine www.youtube.com/watch?v=atCH...
#LDL #cholesterol #ASCVD #statins #PCSK9 inhibitors

#MedSky #EndoSky