I am so proud of this achievement for Sascha. If you want to know about his amazing work that led to this award check out his two preprints: www.biorxiv.org/content/10.1... www.biorxiv.org/content/10.1...

After excising an intron, the spliceosome gets trapped on the branched intron-lariat RNA. How are such dead-end spliceosomes terminated? Our latest paper led by @vytaute.bsky.social investigates the mechanism of spliceosome termination www.nature.com/articles/s41... (1/6)

a fantastic new paper by lab alumni @codyz.bsky.social and yangliu9.bsky.social. Congratulations - such a cool mechanism! check it out 👇👇👇👇👇👇
www.sciencedirect.com/science/arti...

Researchers from our Plaschka lab expected one molecular motor to dismantle the cell’s RNA-editing machine. Instead, they found three. Like three hands untying a knot, the motors act in sequence to take the spliceosome apart: https://bit.ly/4AQnqNQ

Strikingly, @claudioalfieri.bsky.social and his team demonstrate that using cryo-tides, they can obtain high-resolution structures of APC/C, which otherwise requires carbon support.

New preprint from Dodonova lab 🔔! Capturing multiple states by cryo-EM❄️, we show for the first time how archaeal RNA Polymerase engages a nucleosome and forms direct contacts with histones! 🧬
Great work by Gabriele & a fantastic collaboration with Dina Grohmann! 🧵
www.biorxiv.org/content/10.6...

...a lot of people have asked me about our cryo-tides and how they help with preserving particles during cryo-EM grid preparation...and here we go #cryoem: www.biorxiv.org/content/10.6...

First PhD of the Zhang Lab @mrclmb.ac.uk! 🎓✨ Helen successfully defended her PhD thesis last week. So proud to have watched her grow as a researcher and of all she has achieved in her work on the coupling of transcription and splicing! Congratulations, Helen! 🎉