Slow-cooked naïve #Tcells make better effectors. Hee Yeun Won and Jung-Hyun Park (National Cancer Institute) discuss new study from Yamato Sajiki, Koichi Araki et al. @arakilab.bsky.social (rupress.org/jem/article/...) in Insights: rupress.org/jem/article/...

Insights @jem.org: Sajiki et al. @arakilab.bsky.social (rupress.org/jem/article/...) show that long-lived naive #CD8 #Tcells accrue tonic TCR signaling during homeostasis, driving their differentiation into functionally superior effectors. By Hee Yeun Won & Jung-Hyun Park rupress.org/jem/article/...

Insights: Sajiki et al. @arakilab.bsky.social (rupress.org/jem/article/...) show that long-lived naive #CD8 #Tcells accrue tonic #TCR signaling during homeostasis, driving their differentiation into functionally superior effectors. From Hee Yeun Won & Jung-Hyun Park: rupress.org/jem/article/...

Congrats Koichi Araki, @cincyresearch.bsky.social!
Functional heterogeneity and plasticity in naïve CD8 T cells drive superior effector and memory responses
@jem.org
rupress.org/jem/article-...

Sajiki et al. @cincyresearch.bsky.social reveal functional heterogeneity & plasticity within naïve #CD8 #Tcells, identifying functionally superior subsets that can emerge from less potent cells & drive robust immune responses thru. enhanced survival of effector progeny rupress.org/jem/article/...

A nice overview of our new study. Thanks to our media team for putting together this summary!
scienceblog.cincinnatichildrens.org/what-makes-s...

Excited to share our new study! We uncover functional heterogeneity and plasticity within naïve CD8 T cells, showing that highly potent subsets can emerge from less potent cells and promote stronger, more durable immune responses.
rupress.org/jem/article-...