@torbenottlab.org
🧠Neuroscientist | 🎓PI Decision Circuits Lab at Humboldt University and Bernstein Center Berlin, Germany | experiment🔗theory | #behavior #dopamine #serotonin #psychedelics
🌐 https://torbenottlab.org
@seeingwithsound.bsky.socialReposted by @torbenottlab.orgPsilocybin collapses visual change detection and drives cortical dynamics toward a state of surprise (in mice) www.biorxiv.org/content/10.6... by @roberto-defilippo.bsky.social @torbenottlab.org et al.
@neuroskeptic.bsky.socialReposted by @torbenottlab.org"Under psilocybin, expected image repetitions aberrantly recruited change-encoding ensembles and shifted cortical population dynamics towards trajectories normally evoked by genuine stimulus changes." www.biorxiv.org/content/10.6... (In mice)
@torbenottlab.orgThanks to our funders ERC Starting Grant @erc.europa.eu and @dfg.de
@torbenottlab.org6/ Now on BioRxiv: Psilocybin collapses visual change detection and drives cortical dynamics toward a state of surprise. t.co/Y8A4Su3rph #Psychedelics #Neuroscience #PsychedelicScience
@torbenottlab.org5/ Our findings point to a previously unrecognized role for SST interneurons in the acute psychedelic state, potentially linking altered surprise signals to visual distortions.
A huge thank-you to the entire OpenScope team, especially
@jeromelecoq.bsky.social, for making this work possible!
@torbenottlab.org4/ Unexpectedly, psilocybin's effect were not global or uniform but dependent on the image structure: Only images with long, continuous contours recruited change-encoding neurons that were modulated by psilocybin.
@torbenottlab.org3/ Surprisingly, despite this oscillation, image id encoding was completely intact! By contrast, this oscillation was closely linked to CHANGE encoding, pushing visual cortex dynamics in SST interneurons towards states usually associated with surprise.
@torbenottlab.org2/ We found a striking behavioral effect: psilocybin reduced change-detection performance to chance, without causing obvious motor deficits. At the same time, visual stimuli drove a strong 4-Hz oscillation across visual cortex, especially in VISp and SST interneurons.
@torbenottlab.org#Psilocybin🍄 shifts visual cortex dynamics towards a state of surprise! Thrilled to share our work w/ OpenScope at
@alleninstitute.org lead by postdoc @roberto-defilippo.bsky.social. We combined visual change detection w/ Neuropixels recordings in mice to uncover how psilocybin changes circuits 1/
@alexkwan.bsky.socialReposted by @torbenottlab.orgTwo large-scale electrophysiologyical studies of psilocybin's effects in mice, from @alleninstitute.org @torbenott.bsky.social and others.
Should be a treasure trove of data for those interested in perceptual effects of #psychedelics
