@roberto-defilippo.bsky.social
Neuroscience post doc (first gen) torbenottlab.org
@humboldtuni.bsky.social @alleninstitute.org
βπ€πͺπππππππππ€, οΌοΌοΌ¨οΌ΄, πββοΈ, β½οΈ and πΈ
@roberto-defilippo.bsky.socialthanks, if you press on a paper a side panel appears to see the ranking over time, the title on the side panel brings you directly to the paper on biorxiv π
@alexkwan.bsky.socialReposted by @roberto-defilippo.bsky.socialSerotonin biology as a basis for explaining psychedelic drug action - I learned a lot writing this review with @neuroknox.bsky.social
We know a good deal about serotonin, which should teach us how psychedelics work. But whatβs the same? Whatβs different? π€
@roberto-defilippo.bsky.socialToo many neuro preprints to keep track of, so I made a monthly ranking of the most-read ones on bioRxiv. Not a measure of quality, just what people are reading. Here's the fresh ranking for September:
robertodf.github.io/biorxiv-top/
@ivntmc.bsky.socialReposted by @roberto-defilippo.bsky.socialFeeling really proud of this one: a review of Bayesian efficient coding with MΓ‘tΓ© Lengyel and Paul Bays (@bayslab.org) is now available online in TICS!
authors.elsevier.com/a/1nF3i4sIRv...
@neuroskeptic.bsky.socialReposted by @roberto-defilippo.bsky.social"Under psilocybin, expected image repetitions aberrantly recruited change-encoding ensembles and shifted cortical population dynamics towards trajectories normally evoked by genuine stimulus changes." www.biorxiv.org/content/10.6... (In mice)
@roberto-defilippo.bsky.social
@roberto-defilippo.bsky.socialcreated a website to convert any DOI to a elegant banner for presentations robertodf.github.io/doi-banner/
@torbenottlab.orgReposted by @roberto-defilippo.bsky.social6/ Now on BioRxiv: Psilocybin collapses visual change detection and drives cortical dynamics toward a state of surprise. t.co/Y8A4Su3rph #Psychedelics #Neuroscience #PsychedelicScience
@torbenottlab.orgReposted by @roberto-defilippo.bsky.social5/ Our findings point to a previously unrecognized role for SST interneurons in the acute psychedelic state, potentially linking altered surprise signals to visual distortions. A huge thank-you to the entire OpenScope team, especially @jeromelecoq.bsky.social, for making this work possible!
@torbenottlab.orgReposted by @roberto-defilippo.bsky.social4/ Unexpectedly, psilocybin's effect were not global or uniform but dependent on the image structure: Only images with long, continuous contours recruited change-encoding neurons that were modulated by psilocybin.
@torbenottlab.orgReposted by @roberto-defilippo.bsky.social3/ Surprisingly, despite this oscillation, image id encoding was completely intact! By contrast, this oscillation was closely linked to CHANGE encoding, pushing visual cortex dynamics in SST interneurons towards states usually associated with surprise.
@torbenottlab.orgReposted by @roberto-defilippo.bsky.social2/ We found a striking behavioral effect: psilocybin reduced change-detection performance to chance, without causing obvious motor deficits. At the same time, visual stimuli drove a strong 4-Hz oscillation across visual cortex, especially in VISp and SST interneurons.
@torbenottlab.orgReposted by @roberto-defilippo.bsky.social#Psilocybinπ shifts visual cortex dynamics towards a state of surprise! Thrilled to share our work w/ OpenScope at @alleninstitute.org lead by postdoc @roberto-defilippo.bsky.social. We combined visual change detection w/ Neuropixels recordings in mice to uncover how psilocybin changes circuits 1/
@alexkwan.bsky.socialReposted by @roberto-defilippo.bsky.socialTwo large-scale electrophysiologyical studies of psilocybin's effects in mice, from @alleninstitute.org @torbenott.bsky.social and others.
Should be a treasure trove of data for those interested in perceptual effects of #psychedelics
