This piece is accompanied by a multi-stakeholder consensus study on practical fixes for poor antibody validation in research plos.io/3Ui0czP

Researchers often select antibodies based on previous use or peer recommendations. This study shows that poor #antibody validation contributes to substantial avoidable consumption of animal and human biological samples, proposing interventions to improve #reliability.
🧪 #AcademicSky
plos.io/4s1Ccxl

This piece is accompanied by a study on the wasteful consequences of poor antibody validation in research plos.io/4s1Ccxl

Poorly validated #antibodies misdirect research, wasting an estimated billion dollars and millions of biological samples each year. In this multi-stakeholder Delphi consensus study, experts agree on priority practical fixes, and who should deliver them, by 2030.
🧪 #AcademicSky
plos.io/3Ui0czP

Thanks for the post.
Here is the link to the comment journals.plos.org/plosbiology/...

Poorly validated #antibodies generate misleading results and waste research resources. @johanduchene.bsky.social explores two new @PLOSBiology.org studies quantifying these costs and identifying solutions.
🧪
Article 1 plos.io/3Ui0czP
Article 2 plos.io/4s1Ccxl
Primer plos.io/4hQh7kI

🎉 We’re proud to highlight OSC member @johanduchene.bsky.social 's new comment published in @plosbiology.org ! Highlighting the need for antibody validation, it deals with the implications of unreliable antibodies for reproducibility.

#OpenScience #LMU #Reproducibility

journals.plos.org/plosbiology/...

Article#1 about the issue: journals.plos.org/plosbiology/...

Article#2 about the solution: journals.plos.org/plosbiology/...

Better antibodies, better science.

Poorly validated antibodies generate misleading results, waste time and money.

Now, 2 articles and 1 primer in @plosbiology.org
highlight the scale of the problem and what can be done about it.

Primer on the 2 articles:
journals.plos.org/plosbiology/...

🚨 Paper Alert 🚨
Our new study on the impact of a single small zombie trial on fluoxetine's overall efficacy estimation is out.
With great colleagues @floriannaudet.bsky.social @richlyus.bsky.social and Gert van Valkenhoef
🧟‍♂️🧟‍♀️🧟

A longer 🧵

(1/n)

Modern #ScientificPublishing often incentivizes overstating results at the expense of ensuring rigor. @maxkrummel.bsky.social &co test #DiscoveryStack, which seeks to realign #PeerReview with its core purpose by separating the assessment of quality & impact @plosbiology.org 🧪 buff.ly/1GRnb4b

How paper mills fake data, manipulate images, bypass peer review and undermine trust in science.

An investigation by German Quarks show with English subtitles.

youtu.be/Ub2eY8EhTEU?...

The 2026 Lasker-Bloomberg Public Service Award honors Michael J. Fox (Michael J. Fox Foundation for Parkinson’s Research) for empowering patients’ voices and accelerating research to find improved therapies and a cure for Parkinson’s disease. laskerfoundation.org/winners/park...

@sholtodavid.bsky.social
Have you seen this WB from ThermoFisher?

Still anti-p53 antibody, but another clone (MA-12648 instead MA5-12557).

It also looks like that the band in lane 3 was rotated and reused in lane 4.

Moreover, it seems that same band was used for the 2 different clones.

TREM2+ macrophages have rapidly emerged as key regulators in diseases.

Studying them requires specific antibodies.

Among 14 tested antibodies in KO cell lines by WB, 5 are specific.

Pick up the right human TREM2 Antibody.

Full report: tinyurl.com/TREM2Ab
Or here: tinyurl.com/OGA-TREM2