Mann Lab (@mannlab.bsky.social)

@mannlab.bsky.social Oct 9, 2026, 11:37 AM

3/3: Great collaboration across clinic and lab with Rainer Claus & Michaela Kuhlen (Universitätsklinikum Augsburg), Antje Redlich (Universitätsmedizin Magdeburg), the German MET Registry & co-authors in Giessen, Kiel, Bonn & Munich.

@mannlab.bsky.social Oct 9, 2026, 11:37 AM

2/3: ~8,000 proteins per tumour. The 4 states cut across histology and stratify survival more sharply, a 5-protein classifier reproduces them, and each state shows distinct candidate vulnerabilities. A foundation for proteome-informed precision therapy.

@mannlab.bsky.social Oct 9, 2026, 11:37 AM

1/3: Can MS-based proteomics see what histology can’t? We profiled 83 rare paediatric adrenocortical tumours from archival FFPE tissue & found 4 proteome-defined states that predict survival better. Now in @ebiomedicine.bsky.social, led by Rainer Claus & Andreas Metousis. doi.org/10.1016/j.eb...

@mannlab.bsky.social Oct 7, 2026, 11:37 AM

SPARCS: Deep Visual Proteomics-style laser microdissection meets genome-wide CRISPR screening. Find genes behind how cells look, isolate them, profile them by mass spec.
Now in @cellpress.bsky.social
🎉 Congrats to @sophia-maedler.bsky.social and @nik-as.bsky.social, and all co-authors!!

@mannlab.bsky.social Oct 6, 2026, 9:21 AM

400,000 citations! 🎉 Matthias Mann @mannlab.bsky.social just crossed this remarkable milestone on Google Scholar. From electrospray to MaxQuant to Deep Visual Proteomics, he has shaped how the world does proteomics. Congratulations from your team! #Proteomics
scholar.google.com/citations?us...

@mannlab.bsky.social Oct 5, 2026, 12:28 PM

That's a wrap on #HUPO2026 Singapore! 🎉 Congrats to Katherine Madden (🥇 Poster Competition), Elena Kratz (runner-up) & Kathrin Korff (Thesis Competition runner-up). And to alumni Jesper Olsen, Akhilesh Pandey & Florian Rosenberger, & to Judith Steen, on their HUPO awards! 👏

@mannlab.bsky.social Sep 28, 2026, 10:20 AM

New preprint: with ADAPT-MS, discovery plasma proteomics becomes a diagnostic tool for ovarian cancer. We separate benign from malignant adnexal masses and generalize to 5 validation cohorts. Collaboration with @lengyel-ovca-lab.bsky.social
www.medrxiv.org/content/10.6...

@mannlab.bsky.social Sep 25, 2026, 10:41 AM

At #HUPO2026? Come say hi to some of our @mannlab.bsky.social teammates👋 — talks & posters all week on spatial proteomics, plasma biomarkers, a human cell-type proteome atlas, interactomics & AI-driven peptide sequencing. Plenary by Matthias Mann Wed 9:00!

@mannlab.bsky.social Sep 22, 2026, 7:15 AM

This is so well-deserved. Congratulations!

@mannlab.bsky.social Sep 15, 2026, 9:25 AM

Led by @brennsteiner.bsky.social and @lucas-diedrich.bsky.social, with the @scverse.bsky.social proteomics consortium. pip install alphapepttools

@mannlab.bsky.social Sep 15, 2026, 9:25 AM

Proteomics analysis has always lived in its own universe. AlphaPeptTools puts it in #scverse instead, so that proteome, transcriptome and spatial data live in one ecosystem. 11 search engines (DDA+DIA) read in, proteomics-specific statistics, #scverse native.
doi.org/10.64898/202...

@mannlab.bsky.social Sep 10, 2026, 11:54 AM

Congratulations @carolineweiss.bsky.social - fantastic work and well deserved. The future looks bright!

@mannlab.bsky.social Sep 1, 2026, 6:55 AM

Great job on completing your PhD 🙌. Good luck in Sweden, Max — you will do great!

@mannlab.bsky.social Aug 27, 2026, 10:02 AM

Same single cell, two modalities—both at depth. We digest protein first, run Smart-seq3xpress + C18 (Evotip) separation: peptides captured, cDNA in flowthrough. In HeLa & stem cells, proteome tracks cell state; RNA variance flags transitioning cells.
www.biorxiv.org/content/10.6...

@mannlab.bsky.social May 28, 2026, 7:58 AM

1/5
Cell identity is written in the proteome, not in the DNA, and not always in the RNA. Out on bioRxiv today: The first cell type-resolved, MS-based proteomic atlas of the human body.
www.biorxiv.org/content/10.6...

biorxiv.org