Don't miss this review in our latest issue from Lei Wang, Qiuyue Zhang et al. at China Pharmaceutical University discussing how protein phosphorylation can be modulated by proximity-inducing strategies #medchem

Check it out in full below🔽
doi.org/10.1039/d6md...

🔓Check out #OpenAccess research by Bernhard Wünsch & co. @uni-muenster.de in our latest issue synthesising γ-amino alcohols embedded in a 1-benzoxepine scaffold as novel ligands of NMDA receptors with GluN2B subunit #medchem

Read in full on our website👇
doi.org/10.1039/d6md...

⌛There's less than a month left until nominations close for the 2027 @rscmedchem.rsc.org Emerging Investigator Lectureship!

If you know an up-and-coming researcher in drug discovery don't miss the opportunity to nominate them #chemsky #medchem

Full details on how to nominate▶️ rsc.li/md-lectureship

🔓Take a look in our latest issue at a paper by Hidetsugu Tabata, Hideaki Natsugari et al. developing atropisomeric 5N-sulfonyl-1,5-benzodiazepin-2-ones with high inhibitory activity against neutrophil elastase #medchem

📍Teikyo University
doi.org/10.1039/d6md...

🔓Be sure to read #OpenAccess research by Christian Melander & co. from @notredame.bsky.social & @univofmaryland.bsky.social in our latest issue generating sorafenib analogues that exhibit dual Colistin-potentiating and anti-MRSA activity #medchem

Find it in full here🔽
doi.org/10.1039/d6md...

Don't miss the Review behind the inside front cover of our latest issue by Ranjana Pathania et al. from IIT Roorkee discussing AI-enabled discovery of small molecule β-lactamase inhibitors to overcome enzyme diversity and resistance evolution #medchem

doi.org/10.1039/d6md...

📢Our latest issue is now online!

🔓Check out the #OpenAccess Review behind the cover by Ellen E. Hyde & @andrewbeekman.bsky.social from @uniofeastanglia.bsky.social looking at protein–protein interaction inhibitors in the human proteome #medchem

doi.org/10.1039/d6md...

Take a look in our latest issue at research by Kanaka Hettiarachchi & co. describing an integrated platform for accelerating therapeutic macrocyclic peptide purification in high-throughput medicinal chemistry #medchem

📍Merck & Co.
doi.org/10.1039/d6md...

Be sure to read a review from Zahoor Ahmad et al. at CSIR-IIIM in our latest issue looking at strategies for designing polypharmacological agents against multi-drug-resistant tuberculosis #medchem

Find the full article on our website🔽
doi.org/10.1039/d6md...

🔓Don't miss #OpenAccess research by Elena Cichero & co. from University of Genoa probing pyrazolo-pyrimidines as SIRT2 inhibitors via molecular modelling and biological assays #medchem

Check it out in full below👇
doi.org/10.1039/d6md...

Check out research in our latest issue from Qidong You, Lei Wang et al. at China Pharmaceutical University reporting the discovery of DDO-4279 as a PP5 degrader for the treatment of obesity #medchem

Read the full paper here🔽
doi.org/10.1039/d6md...

Take a look at this Opinion article by Matthew W. D. Perry & Rhona J. Cox in our latest issue describing a game to communicate the iterative optimisation of multiple parameters in medicinal chemistry to wider audiences #medchem

📍 @astra-zeneca.bsky.social
doi.org/10.1039/d6md...

Be sure to read in our latest issue a paper from Héctor R. Morbidoni, Guillermo R. Labadie & co. at IQUIR-CONICET exploring the antimycobacterial profile of N-alkyl imidazoles #medchem

Find it in full on our website🔽
doi.org/10.1039/d6md...

Don't miss this research by Bahaa G. M. Youssif et al. from Assiut University in our latest issue developing a series of novel methylene disalicylic acid derivatives targeting DNA gyrase and topoisomerase IV #medchem

Check out their full report below👇
doi.org/10.1039/d6md...

Check out this review from Nicholas S. O'Brien & Adam McCluskey at the University of Newcastle providing an overview of the last twenty years of quinazolines as tubulin polymerisation inhibitors #medchem

Read the full article here🔽
doi.org/10.1039/d5md...

📢We’re excited to announce that nominations for our 2027 Emerging Investigator Lectureship are open

Details about how to nominate: www.rsc.org/standards-an...

We’re looking for up-and-coming researchers in drug discovery within 12 yrs of their PhD.

Nominate before 2 November!
#chemsky #medchem 🧪

🔓Take a look at #OpenAccess research in our latest issue by Zsolt Szakonyi et al. on the synthesis, molecular modelling and evaluation of (−)-isopulegol-based 2,4-diaminopyrimidines as aurora kinase inhibitors #medchem

📍University of Szeged, Vietnam National University
doi.org/10.1039/d6md...

Be sure to read this review by Cong-Jun Liu & co. from Zhengzhou University of Technology in our latest issue discussing strategic selection of linker attachment points in PROTACs #medchem

Find the full article on our website👇
doi.org/10.1039/d6md...