@jamesbriscoe.bsky.social
Developmental Biologist working at the Francis Crick Institute. Neural tube, morphogens, and gene regulatory networks. Editor-in-chief, Development.
London · briscoelab.org
@jamesbriscoe.bsky.socialPhilip Ball wrote a thoughtful popsci piece in @quantamagazine.org on Waddington’s landscape for cell fate decisions
Includes our work with David Rand using dynamical systems theory & single-cell data to make the landscape metaphor quantitative & predictive
@philipcball.bsky.socialReposted by @jamesbriscoe.bsky.socialA weekend read for folks who want to get away from AI, Russian diesel, execution porn, and all that, and just read about some science.
www.quantamagazine.org/how-does-lif...
@wiringthebrain.bsky.socialReposted by @jamesbriscoe.bsky.socialAnother super piece by @philipcball.bsky.social! This one on the enduring impact of "Waddington's landscape"! www.quantamagazine.org/how-does-lif...
@bellecmaelle.bsky.socialReposted by @jamesbriscoe.bsky.socialDNA → RNA → protein.
From single mRNAs to an entire developing vertebrate embryo, we can now watch this last step unfold in real time.
Our paper is out today! 🐟🔬
@crick.ac.ukReposted by @jamesbriscoe.bsky.socialIn a piece in @thelondonstandard.bsky.social, the Crick’s @jamesbriscoe.bsky.social and @charlesswanton.bsky.social explain how AI could help us shift from reactive disease management to proactive prevention and true precision medicine.
Read the full article ➡️ www.standard.co.uk/news/tech/ai...
@jamesbriscoe.bsky.socialNew from Andreas Sagner & co
miRNAs and temporal control of neuronal fate across the vertebrate CNS
Without Dgcr8, progenitors stay early and late-born neurons are lost. Rising miR-9 silences early temporal TFs to promote temporal progression
@jamesbriscoe.bsky.socialReposted by @jamesbriscoe.bsky.socialAI & biomed research. @charlesswanton.bsky.social & I write for the @standard.co.uk.web.brid.gy about how AI can help us in @crick.ac.uk to understand how life works: what keeps us healthy, what sets disease in motion & why patients respond differently
@jamesbriscoe.bsky.socialAI & biomed research. @charlesswanton.bsky.social & I write for the @standard.co.uk.web.brid.gy about how AI can help us in @crick.ac.uk to understand how life works: what keeps us healthy, what sets disease in motion & why patients respond differently
@crick.ac.ukReposted by @jamesbriscoe.bsky.socialWe're looking for undergraduate students at UK universities who are interested in scientific research to join one of our labs or facilities for 12 months as part of our sandwich student programme.
Apply by 6 October: https://www.crick.ac.uk/careers-and-study/students/sandwich-students
@jamesbriscoe.bsky.socialNew work from @spinalorga.bsky.social & co
PAX3 doesn't just pattern the dorsal neural tube, it links metabolism to mechanics
PAX3 sustains upper glycolysis and mannose-dependent glycosylation, which cluster N-cadherin & strengthens adherens junctions
@joadelas.bsky.socialReposted by @jamesbriscoe.bsky.socialIf you are curious about quantitative and predictive cell date decisions landscapes but our 14 figure paper seemed just a bit daunting, have a look at James' linked summary.
@jamesbriscoe.bsky.socialOur latest paper on building models of cell fate decisions -with David Rand, Marine Fontaine & @joadelas.bsky.social- combines developmental biology, dynamical systems theory and bioinformatics. I wrote a short piece to summarise it & explain ideas behind the approach
@dev-journal.bsky.socialReposted by @jamesbriscoe.bsky.socialAt Development, we #LovePostdocs. For #NPAW2026, we highlight our 2026 cohort of Pathway to Independence fellows. Read about their unique journeys as they work to secure independent positions, their excitement about the latest advances in their fields & the advice they have received along the way.
@trayon.bsky.socialReposted by @jamesbriscoe.bsky.socialOur article is on the COVER of this month’s issue of @cp-devcell.bsky.social! Congrats to all the authors for the hard work, especially Shota, Despina and @jamesbriscoe.bsky.social
@jamesbriscoe.bsky.socialPlease email me
@jamesbriscoe.bsky.socialNew book chapter from @jcornwallscoones.bsky.social & me
On GRNs as dynamical systems. Wiring diagrams alone can't predict network behaviour. Understanding developmental patterning needs quantitative, experimentally defined rules for how CREs integrate TF inputs
@dev-journal.bsky.socialReposted by @jamesbriscoe.bsky.social@dev-journal.bsky.social Editor-in-Chief @jamesbriscoe.bsky.social, Editors Liz Robertson and Peter Rugg-Gunn, and Executive Editor @amjeve.uk will be at @warwickuni.bsky.social for #HumanDev26 from 7-9 September 2026.
If you’re also there, do chat with them about your next paper.
@jamesbriscoe.bsky.socialReposted by @jamesbriscoe.bsky.socialOur latest: Dynamic Landscape Analysis of cell fate decisions provides predictive models of neural development from single-cell data
From Marine Fontaine and @joadelas.bsky.social with David Rand in @plosbiology.org
A thread 🧵
doi.org/10.1371/jour...
@jamesbriscoe.bsky.socialIn conclusion, DLA offers a quantitative & generative framework to study cell fate decisions
This is an ongoing collaboration with David Rand driven by Marine Fontaine & @joadelas.bsky.social who did this together
Thanks to Meri Sáez, Rory Maizels, Lizzie Finnie
@jamesbriscoe.bsky.socialThe model challenges the conventional French flag picture The pMN/p3 and p3/FP boundaries arise from branching decisions, not from thresholds along a monotonic gradient Patterning is hierarchical, and the landscape becomes a testable object Clonal lineage tracing is the next test
