preLights

@prelights.bsky.social

A preprint highlights service run by the biological community and supported by The Company of Biologists (@biologists.bsky.social).

@tessamontague.bsky.socialReposted by @prelights.bsky.social

I'm excited to share our new preprint: Generation of a transgenic cephalopod
tinyurl.com/pc86jxz8

Cephalopods (cuttlefish, octopus & squid) are crazy critters that dynamically camouflage to their surroundings by changing the color, pattern, & texture of their skin, which they control w their brain.

@felicie-dhellemmes.bsky.socialReposted by @prelights.bsky.social

Proud to present our latest work "Tracking human foragers and their prey reveals adaptive predator-prey dynamics", now hosted on BioRxiv! 🧵

doi.org/10.64898/202...

@ralfkurvers.bsky.social @scioi.bsky.social @arc-mpib.bsky.social @alexschakowski.bsky.social @dominikdeffner.bsky.social

@anderssonlab.bsky.socialReposted by @prelights.bsky.social

🧬 Preprint! 🧵 Our goal is to genetically manipulate every embryonic germ layer to enable high throughput in vivo studies. We previously showed mouse ectoderm can be targeted by amniotic injection, enabling cell-specific manipulation, lineage tracing, and knockouts. But how to reach mesoderm?

Schematic of method developed and application. At embryonic day 7.5, a lentiviral library carrying unique 30-nucleotide barcodes and a fluorescent reporter is injected into the mouse exocoelomic cavity. An E8 embryo cross-section shows that this cavity is continuous with the intraembryonic coelomic cavity, allowing the virus to reach and barcode mesodermal progenitors, including lateral plate and paraxial mesoderm.
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