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Earlham Institute

@earlhaminst.bsky.social

752 Following2.1k Followers

Combining world-class technology and interdisciplinary expertise across genomics, engineering biology and data science to accelerate solutions for health, biodiversity, and food security.β€―

πŸ“ Norwich, UK
πŸ”— earlham.ac.uk

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@earlhaminst.bsky.socialOct 10, 2026, 1:00 PM

πŸ’¬ "If you only have an engineer, they might not be able to recognise whether an issue is down to a technical problem with the robot or a fundamental biological process.” 

πŸ“– Read: 'Where biology meets automation: Inside the Earlham Biofoundry' with Davide Annese πŸ‘‡

#automation #synbio

@earlhaminst.bsky.socialOct 10, 2026, 9:00 AM

Are you looking to develop your skills in plant, microbial, and data science? 🌱🧫🧬

Applications are now open for the John Innes Foundation Rotation PhD Programme in Plant and Microbial Sciences at the @John Innes Centre, @The Sainsbury Laboratory and The Earlham Institute πŸ‘‡

@halllab.bsky.socialOct 9, 2026, 7:30 AMReposted by @earlhaminst.bsky.social

Huge congratulations to @hannahtriv.bsky.social and the team on this fantastic work! πŸ‘

Brilliant to see long-read metagenomics revealing new insights into the gut microbiome and antimicrobial resistance in advanced liver disease.

Highlights the potential role of MDR Enterococcus in cirrhosis! 🧬🦠

@hannahtriv.bsky.socialOct 8, 2026, 7:21 PMReposted by @earlhaminst.bsky.social

Delighted to share our new paper in Genome Medicine! We used long-read #metagenomics to uncover striking changes in the gut #microbiome with advanced #LiverDisease, including E. faecium dominance and #AMR
@halllab.bsky.social

#Genomics #ECR #Resistome #Cirrhosis

link.springer.com/article/10.1...

@earlhaminst.bsky.socialOct 8, 2026, 11:03 AM

Inspired by the potential of #automation to accelerate synthetic and #engineeringbiology,Β Davide Annese develops automated workflows helping scientists navigate hurdles of speed, scale, and precision. πŸ‘‡

https://okt.to/FLQqnh

@earlhaminst.bsky.socialOct 7, 2026, 2:00 PM

πŸ†• Applications are open for a new 3-year Postdoctoral role developing novel computational and mathematical methods to resolve the #genomic diversity of the soil microbiome.

πŸ“… Apply by: 13 November 2026

#soil #microbiome

@earlhaminst.bsky.socialOct 7, 2026, 9:00 AM

πŸ“£ Save the date! The Norwich #SingleCell and #Spatial Symposium returns in 2027.

Join a supportive forum for researchers working on similar challenges across diverse systems to discuss, network, and share knowledge.

πŸ“ Register your interest to hear more!
πŸ—“οΈ 22-23 June 2027

@earlhaminst.bsky.socialOct 6, 2026, 1:00 PM

With both pipelines and a Galaxy workflow available, the developers welcome the #scRNAseq and #spatial community to use and test the pipelines, and suggest features to help shape future developments.

@earlhaminst.bsky.socialOct 6, 2026, 1:00 PM

A new preprint introduces two standardized, end-to-end pipelines for single-cell RNA-seq and imaging-based #spatialtranscriptomics analysis.

EISCA supports droplet- and plate-based scRNA-seq, while EISTA is tailored for high-resolution spatial platforms.

#SingleCell #RNAseq

@metalichen.bsky.socialOct 1, 2026, 11:20 AMReposted by @earlhaminst.bsky.social

Our review on #lichen research in the #omics era is out in @lichenologist.bsky.social! We discuss omics-driven progress and outline several areas and methods that we think especially promising for lichen biology, such as single-cell omics and epigenomics
πŸ–₯️ πŸ§ͺ 🦠 🧫 #SymbioSky doi.org/10.1017/S002...

The infographic is divided into three columns.

Column 1: Sample Types.

At the top is a photo of a yellow Lichen Thallus. An arrow points down to a cross-section diagram showing green algal cells embedded in white fungal hyphae. Below this is Isolate Cultures, showing a petri dish and a test tube containing green liquid.

Column 2: Omics.

- Genomics: Assembly of D N A sequences into complete genomes, illustrated by blue horizontal bars and a double helix icon.

- Transcriptomics: Quantifying expression of genes, shown as small green segments aligning to a dark blue reference genome.

- Metabolomics: Analysis of metabolites, represented by a chemical molecular structure.

- Proteomics: Characterization of proteins, shown as a blue 3 D protein folding model.

- Epigenomics: Exploration of genome modifications, illustrated by blue circles representing histones wrapped in D N A with hexagonal tags.

Column 3: Advances and Opportunities.

- Evolution of lichenization: A phylogenetic tree paired with a horizontal bar chart.

- Gene regulation: A line graph showing chromatin accessibility and a heatmap for motif enrichment analysis. Below is a D N A sequence motif: C G C G A A A A A A.

- Symbiont interaction: A diagram comparing a bulk sample to isolated nuclei using single-cell transcriptomics, visualized with a stacked bar chart showing different cell population proportions.
@earlhaminst.bsky.socialOct 6, 2026, 7:00 AM

Later this month, Group Leader Dr @Sarah Guiziou will be at @European Synthetic Biology Society presenting her group's research using recombinase and integrase genetic tools to record gene expression with single-cell resolution and engineer plant development. 🌱🧬 πŸ—“οΈ Tuesday 20 October

@earlhaminst.bsky.socialOct 5, 2026, 2:52 PM

πŸ’¬ β€œThrough COPO we have spent years developing meaningful standards and tooling which properly describe research data. This multiplies its usefulness, making it comparable, reusable and trainable for the community at large."

#FAIRdata #ResearchDataManagement #biodiversity

@earlhaminst.bsky.socialOct 3, 2026, 9:00 AM

With prerequisite materials made available, this course will take you through end-to-end the workflow for generating, processing, and interpreting long-read RNA-seq data - specifically in the context of #singlecell experiments.

πŸ§¬πŸ’»

@earlhaminst.bsky.socialOct 3, 2026, 9:00 AM

Registration closes soon for our hands-on training course in #longread #scRNAseq, covering everything from experimental design to data interpretation with our research faculty.

https://okt.to/Y8HrpT

@earlhaminst.bsky.socialOct 2, 2026, 10:10 AM

From scripting robots to troubleshooting experiments, Davide Annese brings together biology and automation expertise at the Earlham #Biofoundry.

In a new article find out how automated workflows are helping researchers tackle high-throughput biology. πŸ§¬πŸ€–πŸ”

#synbio #automation

@earlhaminst.bsky.socialSep 30, 2026, 1:00 PM

πŸ’¬ "The role ARIA has given to data management across this priority area demonstrates how vital FAIR data management is in enabling discovery and innovation."

https://okt.to/elVur2

@earlhaminst.bsky.socialSep 30, 2026, 9:00 AM

'Full-Spectrum Pipelines for Single-Cell and Spatial Transcriptomics Analysis' is now available on bioRxiv, with both pipelines available on GitHub.

Read more below πŸ‘‡
https://okt.to/Ho3Qac

@earlhaminst.bsky.socialSep 30, 2026, 9:00 AM

πŸ’¬ "We invite researchers to try these pipelines on their own single-cell and spatial transcriptomics datasets and encourage users to report issues and suggest feature requests to help shape future developments." - Huihai Wu, Senior Bioinformatician at Earlham Institute.

@earlhaminst.bsky.socialSep 30, 2026, 9:00 AM

πŸ“ƒ In a new preprint, scientists introduce two standardized, end-to-end pipelines for single-cell RNA-seq and imaging-based #spatialtranscriptomics analysis.

EISCA supports droplet- and plate-based scRNA-seq, while EISTA is tailored for high-resolution spatial platforms.

#SingleCell #RNAseq

@earlhaminst.bsky.socialSep 29, 2026, 4:00 PM

Join our new training course for hands-on experience in long-read #scRNAseq, covering everything from experimental design to data interpretation with our research faculty.

Find out more below ‡️

#longreads #singlecell #RNAseq

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