Journal of Cell Science

@jcellsci.bsky.social

Journal of Cell Science (JCS) publishes cutting-edge science encompassing all aspects of cell biology. JCS is a community journal published by The Company of Biologists (@biologists.bsky.social), a not-for-profit organisation. #cellbiology #cellbio

@henriqueslab.bsky.social Oct 12, 2026, 9:34 AMReposted by @jcellsci.bsky.social

🚀 Rxiv-Maker is now peer-reviewed and open access! Write your manuscript in Markdown and get a typeset PDF or an editable Word file, with figures, citations and cross-references numbered for you. Led by Bruno Saraiva, with @guijacquemet.bsky.social's lab 🔬

doi.org/10.1242/jcs.265183

Top of the first page of the published article 'Rxiv-Maker – an automated template engine for streamlined scientific publications' by Bruno M. Saraiva, Rita Carlota, António D. Brito, Iván Hidalgo-Cenalmor, Guillaume Jacquemet and Ricardo Henriques, showing the title, authors and abstract.

@kazu-maeshima.bsky.social Oct 12, 2026, 7:23 AMReposted by @jcellsci.bsky.social

Our new paper is out @jcellsci.bsky.social 🧬✨ doi.org/10.1242/jcs.... @ynagata.bsky.social et al combined single-nucleosome imaging + Fucci probes. H2B-Halo motion stays nearly constant from G1 to G2. H3.3-Halo euchromatin nucleosomes are more mobile, but their motion also stays nearly constant.

@biologists.bsky.social Oct 12, 2026, 10:02 AMReposted by @jcellsci.bsky.social

Looking to attend a #microscopy training course? Don't miss the 16 October deadline to apply for a grant of up to £1,000 from @jcellsci.bsky.social and @focalplane.bsky.social
Find out more at www.biologists.com/grants/jcs-f...

@jcellsci.bsky.social Oct 9, 2026, 1:26 PM

This article is associated with a field maple tree, planted in The Forest of Biologists.
forest.biologists.com/landscape/

Tree no. 19250
Field maple (Acer campestre)

Sturdy broad-leaved deciduous tree, with a wide ecological range and natural distribution over most of Europe. Field maple has a light brown and flaky bark, with brown slender twigs that develop corky ridges with age. Its small, dark-green leaves have five lobes with rounded teeth, and fade to a rich golden-yellow or red before falling in autumn. A hermaphroditic species – its small, yellow-green, clustered flowers are pollinated by insects and develop into large, winged crimson fruits (samaras) that are dispersed by wind.

Field maple has a compact habit and grows in woods, scrub and hedgerows. While extremely tolerant to shade during the first decade, its light requirements are higher in seed-bearing years. It prefers warmer climates, but can also tolerate hard winters. Highly resistant to air pollution, the trees are widely planted in gardens and parks.

@jcellsci.bsky.social Oct 9, 2026, 1:26 PM

In their Review, Anastasia Zhurikhina, Maia Kirkegaard, Alberto Guarnieri and Hanna Martens discuss the mechanisms and mechanics of #aging.
journals.biologists.com/jcs/article/...

Schematic showing age-associated disruption of the ECM–cytoskeleton–nucleus mechanotransduction axis. Top, in young cells (i.e. cells from young donors or animals, or early-passage cultures with normal proliferative capacity and morphology), ECM engagement promotes activation and clustering of αβ integrins and assembly of focal adhesions (FAs) containing talin, vinculin, paxillin, FAK and Src. These structures couple the ECM to aligned actin stress fibers and the perinuclear actin cap, enabling force transmission to the nucleus through the LINC complex [SUN1 and/or SUN2 (SUN1/2) with nesprin] and an intact nuclear lamina. PIEZO1-mediated Ca2+ influx promotes FAK–Src and PI3K–AKT signaling and further supports mechanosensitive transcriptional programs mediated by the transcription factors (TFs) YAP/TAZ–TEAD, MRTF–SRF, β-catenin and KLF2 and KLF4 (KLF2/4), impacting genes involved in nuclear envelope (NE) integrity, cytoskeletal integrity, osteogenesis and vasculoprotection, respectively. Bottom, in aged and senescent cells (i.e. cells from aged donors or animals, or replicatively or stress-induced senescent cultures, as defined in the cited studies by stable proliferative arrest together with one or more established senescence markers), integrin composition and focal adhesion assembly are altered, actin organization is disrupted and microtubules (MTs) become excessively stabilized. Reduced SUN2 expression and loss of lamin B1 weaken nucleo-cytoskeletal coupling, de-repress heterochromatin and reduce PIEZO1 expression. Together, these changes blunt mechanosensitive transcriptional responses and impair force transmission from the ECM to the genome. Created in BioRender by Guarnieri, A., 2026. https://BioRender.com/9lv8rls. This figure was sublicensed under CC-BY 4.0 terms.

@jcellsci.bsky.social Oct 8, 2026, 7:56 AM

New JCS snapshot - Outer kinetochore proteins form linear elements to regulate vesicle transport

Shane Kowaleski presents the key findings from their JCS paper with Joshua Bembenek and team.
journals.biologists.com/jcs/article/...

@jcellsci.bsky.social Oct 7, 2026, 10:24 AM

Also in Issue 18:
- Research Highlights on lamin assembly, organelle dynamics in plant cells, prions & mitochondria function and stress granules
- The pyrenoid at a glance
- Review on the mechanisms and mechanics of aging
journals.biologists.com/jcs/issue/13...

Journal of Cell Science poster
The pyrenoid at a glance
Philippe Van der Stappen, Benjamin D. Engel, Manon Demulder

@jcellsci.bsky.social Oct 7, 2026, 10:24 AM

Issue 18 is complete

Explore our Toc: journals.biologists.com/jcs/issue/13...

Our cover image is an osteosarcoma cell visualised by structured illumination microscopy showing actin (magenta), paxillin (green) & myosin-X (cyan). See research by Popović et al.
journals.biologists.com/jcs/article/...

JCS cover: An osteosarcoma cell visualised by structured illumination microscopy. The actin cytoskeleton is shown in magenta, paxillin in green and myosin-X in cyan. See article by A. Popović et al. (jcs265278).

@ucsfaging.bsky.social Oct 6, 2026, 4:08 PMReposted by @jcellsci.bsky.social

BARI spotlight: Hanna Marten’s review traces how matrix crosslinking, weak adhesions, and nuclear fragility feed senescence, and how that loop further degrades tissue mechanics. A clear case for resetting the aged mechanical niche. #aging #ECM
journals.biologists.com/jcs/article/...

@anagracanin.bsky.social Oct 6, 2026, 9:35 AMReposted by @jcellsci.bsky.social

Started with looking at MS list and thinking: "What the hell is CCT8?" Ended with: It directly binds MYO10 motor (Yes! MOTOR! Amazing!) domain! Comes with a beautiful MYO10-proximal (khm filopodial khm) proteomes from TWO cell lines. How similar are they? Is your favourite protein there?Take a peak!

@jcellsci.bsky.social Oct 6, 2026, 8:25 AM

This article is available under our Read & Publish Open Access initiative.
Researchers can find out about the wide range of benefits, read what researchers are saying and view a list of participating institutions at www.biologists.com/library-hub/...

#OpenAccess #ReadandPublish

@jcellsci.bsky.social Oct 6, 2026, 8:25 AM

Ana Popović @anagracanin.bsky.social, Guillaume Jacquemet @guijacquemet.bsky.social and colleagues discover that CCT8 associates with the MYO10 motor domain and regulates #filopodia and breast cancer cell invasion.
journals.biologists.com/jcs/article/...

Figure showing that CCT8 modulates filopodia formation independently of the TRiC.

@jcellsci.bsky.social Oct 5, 2026, 8:35 AM

Read more about this research in our ‘First person’ interview with Elizabeth-Ann Legere. In this interview, Elizabeth-Ann shares that part of this research was supported by a @biologists.bsky.social Travelling Fellowship to visit @glgalea.bsky.social’s lab.
journals.biologists.com/jcs/article/...

@jcellsci.bsky.social Oct 5, 2026, 8:35 AM

Elizabeth-Ann Legere, Aimee Ryan @rimuhc.bsky.social and colleagues discover that increased tissue tension caused by depletion of CLDN3 in the non-neural ectoderm causes neural tube defects in chick embryos.
journals.biologists.com/jcs/article/...

Figure showing that CLDN3 depletion decreases the rate of neural fold movement during fusion.

@cellarchlab.com Oct 2, 2026, 9:17 AMReposted by @jcellsci.bsky.social

Nice @jcellsci.bsky.social "at a glance" review about the convergently evolved organizing principles of pyrenoids, chloroplast compartments that enable diverse algae to supercharge #CO2 fixation. BONUS: It comes with a poster for your wall 🖼️. Great work @phaips.vd.st & @manondemulder.bsky.social 🌊🌾🧪

@biologists.bsky.social Oct 2, 2026, 11:03 AMReposted by @jcellsci.bsky.social

Thank you Erdinc Sezgin @sciezgin.bsky.social for sharing your experience of fee-free #OA publishing @jcellsci.bsky.social via our #ReadAndPublish agreement with Karolinska Institute, Sweden @ki.se

Read Erdinc’s paper: doi.org/10.1242/jcs....

Is your institution participating too? bit.ly/3O7BxGi

I am delighted that our paper has been published Open Access in Journal of Cell Science, supported by the agreement with Karolinska Institutet. It is especially rewarding to know that the funds invested to make our paper Open Access will be spent wisely and responsibly by The Company of Biologists to support research and researchers.

@jcellsci.bsky.social Oct 2, 2026, 7:48 AM

#OpenAccess #ReadandPublish

@jcellsci.bsky.social Oct 2, 2026, 7:48 AM

Infectious prions strain mitochondrial function

Daniel Shoup, Suzette Priola & team find that exposure of cells to prions induces changes in #mitochondrial redox state & respiration.

Highlight: journals.biologists.com/jcs/article/...
Article:
journals.biologists.com/jcs/article/...

Figure showing that mitochondria take on a more oxidizing environment after exposure to 22L PrPSc BH.

@jcellsci.bsky.social Oct 1, 2026, 8:48 AM

This article is associated with a silver birch tree, planted in The Forest of Biologists.
forest.biologists.com/landscape/

Tree no. 19249
Silver birch (Betula pendula)

Medium-sized deciduous tree, native to the British Isles. Known for its white bark, which sheds in strips. It has small, light-green, triangular leaves. Male and female catkins are found in the same tree (monoecy), with wind pollination and wind dispersal of seeds.

With fast early growth, birch is a useful pioneer species. Birch trees can also improve soil quality by recycling nutrients. Birch is frost resistant and windfirm but planted trees can be vulnerable to birch dieback (caused by fungal pathogens). Naturally regenerated birch – grown from seeds that have fallen from a tree – appear less prone to disease but climatic variables also play a part. Birch woods have a light canopy, encouraging the growth of other plants on the forest floor, and are valuable to wild life.

@jcellsci.bsky.social Oct 1, 2026, 8:48 AM

A new lamin assembly assay using Xenopus egg extracts

Ross Pedersen, Yixian Zheng and colleagues reconstitute lamin assembly on nuclear pore complex-containing membranes.
Highlight: journals.biologists.com/jcs/article/...
Article: journals.biologists.com/jcs/article/...

Figure showing that lamin-B3 assembly occurs on annulate lamellae in the absence of nuclei.

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