@ewingt-phd.bsky.social
Drug Discovery / Aging / Fitness
Convincing myself that aging is simply loss of regulation/repair and CAN BE reversed!
I wrote a book! BIOLOGICAL YOUTH http://amazon.com/dp/1535584459
@ewingt-phd.bsky.socialTop-ranked metabolism pathways: — glycine, serine, and threonine metabolism — butanoate metabolism — cysteine and methionine metabolism🧪
@ewingt-phd.bsky.socialChinese researchers develop plasma metabolite model of #aging
www.science.org/doi/10.1126/...
— laser desorption/ionization mass spectrometry (LDI-MS)
— identified 56 representative age-associated metabolites
— accelerated aging by model associates with chronic disease, mortality
#longevity 🧪🧬🛟🩺📈
@ewingt-phd.bsky.socialScreen identifies SRSF1 as aging regulator🧪🧬
www.nature.com/articles/s43...
@atanas-g-atanasov.bsky.social
@bakersm11.bsky.social
@mljtpa.bsky.social
@jngljane.bsky.social
@mfamyfuerza.bsky.social
@42ndhumanbeing.bsky.social
@erlangen.bsky.social
@diana180.bsky.social
@esiobhanmitchell.bsky.social
@ewingt-phd.bsky.socialResearchers @harvard.edu suspect they found #longevity gene?
wyss.harvard.edu/news/reversi...
— typical cell reprogramming via de-differentiation risks cancer
— cell age of donor correlates with gene expression profile
— cell age reduced via up-regulation of SRSF1 splicing factor
@ewingt-phd.bsky.social@ewingt-phd.bsky.socialDNA methylation clocks & reproductive history🧪🧬
www.sciencedirect.com/science/arti...
@atanas-g-atanasov.bsky.social
@bakersm11.bsky.social
@mljtpa.bsky.social
@jngljane.bsky.social
@mfamyfuerza.bsky.social
@42ndhumanbeing.bsky.social
@erlangen.bsky.social
@diana180.bsky.social
@dricks.bsky.social
@ewingt-phd.bsky.socialEarlier #menopause correlates with faster #epigenetic #aging
medicine.nus.edu.sg/news/earlier...
— meta-analysis of 29 studies involving 550,550 women
— each 1y earlier age at menopause associates with about one month of greater DNA methylation aging
@ewingt-phd.bsky.socialGreat Qs I'm new to the C15 FA research. I'll keep an eye on it as I begin reading more about it Likely C15 FA is promiscuous binder to many metabolic targets/pathways, so it's effects could manifest broadly and in non-linear dose-dependent manner eg. agonism/antagonism switching across doses
@funkyzulu.bsky.socialReposted by @ewingt-phd.bsky.socialThis right here 👇🏽
@ewingt-phd.bsky.socialSenescence, Exercise, Aging in the Heart🧪🧬
onlinelibrary.wiley.com/doi/10.1111/...
@atanas-g-atanasov.bsky.social
@bakersm11.bsky.social
@mljtpa.bsky.social
@jngljane.bsky.social
@mfamyfuerza.bsky.social
@42ndhumanbeing.bsky.social
@erlangen.bsky.social
@diana180.bsky.social
@dricks.bsky.social
@ewingt-phd.bsky.socialExercise is a natural #senolytic!
bioengineer.org/senolytic-dr...
Mouse study spanning entire second half of life
— aerobic exercise worked as well as drugs to suppress cell senescence in heart
— both interventions preserved heart function
I highly recommend regular strength + endurance training
@ewingt-phd.bsky.socialBtw I consider transposable elements to be a cause of age-related #genome instability for us humans!
Our nuclei employ piwi-RNA and Dicer RNAse along with nightly re-methylation to suppress transposable elements
The immortal freshwater hydra happen to have exceptional piwi-RNA/Dicer machinery 🧬
@ewingt-phd.bsky.socialSize-related lifespan compression in dogs🧪
www.science.org/doi/10.1126/...
@atanas-g-atanasov.bsky.social
@bakersm11.bsky.social
@mljtpa.bsky.social
@jngljane.bsky.social
@mfamyfuerza.bsky.social
@42ndhumanbeing.bsky.social
@erlangen.bsky.social
@diana180.bsky.social
@princess-vimentin.bsky.social
@ewingt-phd.bsky.socialBig dogs, little dogs, #aging, #epigenome & #transposons
www.nature.com/articles/d41...
— Study of ~900 dogs from ~120 breeds
— Big dogs die earlier, accumulate epigenetic changes faster
— gene promoters gain methylation
— introns & transposons lose methylation (activate)
via @nature.com
@ewingt-phd.bsky.socialYou don't have to insist on it I do though, since I live in the US where science is under attack Research doctors need to stick up for each other and promote our expertise to fight against the ignorance in US politics that is causing misery, morbidity and mortality to millions of Americans 🧪
@ewingt-phd.bsky.socialYeah I've heard this one before It really makes me laugh How would people on the plane possibly know you were a research doctor? "Is there a doctor on the plane? We have an emergency!" "Is it a medical emergency or a research emergency? I'm a research doctor if someone has a science question"
@ewingt-phd.bsky.socialC15 fatty acid alleviates atherosclerosis🧪🧬🩺
www.nature.com/articles/s41...
@atanas-g-atanasov.bsky.social
@bakersm11.bsky.social
@mljtpa.bsky.social
@jngljane.bsky.social
@mfamyfuerza.bsky.social
@42ndhumanbeing.bsky.social
@erlangen.bsky.social
@diana180.bsky.social
@esiobhanmitchell.bsky.social
@ewingt-phd.bsky.socialChinese researchers notice link between gut #microbe, #metabolite & #atherosclerosis
www.nature.com/articles/d41...
— stool levels of Bacteroides uniformis often depleted in those with heart disease compared with healthy individuals
— blood levels of metabolite C15 pentadecanoic acid also depleted
@ewingt-phd.bsky.socialYes, I've met many MD PhDs They seem to have a few common traits Highly motivated & intelligent, but high strung & stressed out
@ewingt-phd.bsky.socialYes I agree general public familiar with medical doctors with MD suffix But we're teachers! We need to *teach* the general public that research doctors have PhD suffix, just like psychologists Btw, many medical doctors too busy to keep up with latest medical research & need OUR help to keep up!
