What makes CLDN7 lose its #TumorSuppressive power?
This study shows that APT1-driven #depalmitoylation destabilizes CLDN7, promoting #ccRCC invasion and revealing APT1 inhibition as a potential therapy. @pku1898.bsky.social
#OpenAccess #GenesAndDiseases: doi.org/10.1016/j.ge...

“PGC1α-mediated upregulation of PHD2 represses HIF-signaling, limiting prostate cancer progression”

PGC1 represses HIF signaling via ERR-driven EGLN1 transcriptional induction, expanding its #TumorSuppressive role in #PCa ⤵️
nature.com/articles/s41...