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@alicefrolov.bsky.social Oct 6, 2026, 5:00 PM

New visualization: "The oxidative tipping point: ROS output outpaces antioxidant defense across the lifespan"

#RedoxBiology #MitochondrialBioenergetics #OxidativeStress #ReactiveOxygenSpecies #ElectronTransportChain #NRF2Signaling #FreeRadicalBiology

New visualization: "The oxidative tipping point: ROS output outpaces antioxidant defense across the lifespan"

Subtitle: Simulated mitochondrial superoxide flux (left) vs enzymatic antioxidant capacity (right) per tissue and age.

I am sharing a diverging paired-lollipop balance plot developed to communicate the divergence between mitochondrial reactive oxygen species generation and enzymatic scavenging capacity as a function of chronological age across four representative tissues (myocardium, skeletal muscle, hepatic parenchyma, and cortical neurons). I want to emphasize at the outset that the underlying values are simulated; they are parameterized to reproduce qualitative trends reported in the redox biology literature rather than to represent empirical measurements from a specific cohort.

The mirror-lollipop geometry places superoxide flux on the left axis and combined antioxidant capacity (aggregating SOD2, catalase, and glutathione peroxidase activity) on the right, with a shared central baseline. This layout makes the widening asymmetry between the two arms readily interpretable per tissue-age stratum. The left-hand stems model electron leak at Complexes I and III, scaled to reflect the age-associated decline in electron transport chain coupling efficiency and the attendant increase in single-electron reduction of molecular oxygen. The right-hand stems encode declining enzymatic detoxification, incorporating the documented attenuation of NRF2-mediated transcriptional responses with advancing age.

The central mechanistic claim rendered by the figure is the crossover point at which ROS output exceeds buffering capacity, initiating a self-amplifying regime of macromolecular oxidation, mtDNA lesion accumulation, and further ETC dysfunction. Post-mitotic tissues (neurons, myocardium) reach this inflection earlier in the simulated trajectory, consistent with their limited mitochondrial turnover.

@efbiotechnology.org Sep 28, 2026, 12:38 PM

📢 Registration & abstract submission are now open for the 𝗣𝗿𝗼𝗸𝗮𝗿𝘆𝗼𝘁𝗶𝗰 𝗘𝗹𝗲𝗰𝘁𝗿𝗼𝗻 𝗧𝗿𝗮𝗻𝘀𝗳𝗲𝗿 Conference!
📍 Évora, PT
📅 10–13 March 2027
Join researchers on microbial #ElectronTransfer, #bioenergetics, #RedoxBiology & more
@axelmagalon.bsky.social @sofiapauleta.bsky.social @david-s-richardson.bsky.social

Prokaryotic Electron Transfer Conference

@sfrre-ecr.bsky.social Sep 17, 2026, 4:32 PM

🎓 PhD students in redox biology: this is your moment!

🏃 Join the 4th PhD Symposium "Redox Relay Race" 🗓️ 17-18 Nov 2026 🎤 5-min flash talks 📝 Submit your abstract (≤300 words) by 15 Oct

🏆 Best talk wins free registration to SFRR-E 2027 in Porto 🇵🇹

#CallForAbstracts #PhDSymposium #RedoxBiology