Traver Hart’s team evaluated a 77,000 dual-gRNA Cas12a library on bioRxiv, revealing that dual-target locus excision operates at very low efficiency in mammalian screens due to asynchronous cleavage dynamics. 🧬🤖
#CRISPR #Cas12a #bioRxiv2026 #MDAnderson #GeneEditing #FunctionalGenomics