Loss of AhR enables BRAFV600E-positive #Cancer cells to escape #MAPK blockade by increasing ARNT–SMAD2/3 interactions and TGF-β-dependent transcription, revealing a mechanism underlying resistance to BRAF/MEK-targeted therapy. @uofcalifornia.bsky.social

#STTT #OpenAccess: doi.org/10.1038/s413...

This review maps the IGF/IGFR signaling network and its crosstalk with PI3K–AKT, #MAPK/ERK and other pathways, connecting context-specific signaling to diverse diseases and opportunities for targeted therapies. #Cancer

#STTT #OpenAccess: doi.org/10.1038/s413...