#ChangeTheDogma! #TLRpower! @jkagan1.bsky.social @danielhfisch.bsky.social &co show @nature.com that TRAM, so far believed to control endosomal TLR4 signaling & interferon #IFN production, is essential to release the #myddosome from #TIRAP & the plasma membrane allowing full NFkB signaling!

#InterferonPower! Excited for a small contribution to the fantastic work by @mehandrulab.bsky.social, Parekh &co @naturemedicine.bsky.social showing that #enterocolitis driven by B cell-targeted #CAR-T cells is associated with increased #IFN signaling & can be dampened by JAK inhibitors!

Super excited to share this Forum article just out in @cp-trendsimmuno.bsky.social in which we discuss how dyregulated #IFN signalling can perturb #HSC 🩸 in Inborn Errors of Immunity #IEI that mainly affect nonhematological tissues

www.sciencedirect.com/science/arti...

#WeekendRead! #ImmunometabolismPower #SmartTumor! Jia, Zhang &co using in vivo CRSPR show @ #ScienceImmunology that in low glucose, tumor cells steal glutamine to produce antioxidant glutathione, preventing #mitochondrial mtDNA release, #STING activation, type I #IFN & CD8 T cell antitumor activity!