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@yeastgenome.bsky.social Oct 5, 2026, 6:03 PM

The first integrated #eukaryotic #genome #database has now been running for 30+ years. 🧬 A new history of #SGD traces how a #Stanford #yeast database became a global hub for #genetics, functional #genomics & #humanDisease research. 📄 bit.ly/SGD30FEMSYeast #bioinformatics

Thirty years of sustained growth in SGD literature coverage and biological annotation. The figure shows two measures of SGD’s expansion from 1996 to 2025. The black line represents cumulative papers incorporated into the database, reflecting the pace at which published yeast research has been integrated. Stacked bars show cumulative annotations across major annotation types, ordered from bottom to top by year of first curation: locus summaries (orange, since 1999), GO annotations (green, since 2002), phenotype annotations (blue, since 2006), allele annotations (red, since 2006), regulation annotations (purple, since 2016), PTM annotations (cyan, since 2017), disease annotations (pink, since 2018), and functional complementation (brown, since 2021). The progressive accumulation of annotation types, visible as new colored segments appearing over time, illustrates SGD’s transformation from a genome sequence database into a comprehensive biological knowledge resource. Three vertical dashed lines mark key milestones in SGD’s history: (1) database launch and first annotations, (2) adoption of GO, and (3) expansion into disease-focused curation. By 2025, SGD contained ~100 000 papers and over 500 000 annotations spanning diverse data types.

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