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@plosbiology.orgSep 28, 2026, 4:31 PM

Cationic amphiphilic drugs (CADs) can disrupt lysosomal function. Peter Roy &co show that a xenobiotic module couples CYP-35B–mediated CAD catabolism to efflux in #Celegans, possibly to #detoxify natural products generated by microbes in the soil 🧪 buff.ly/4BFpg7V

Working model of the CAD Defense Pathway. CAD metabolites and polar lipids are exported by PGP‑13 and PGP‑14 across the plasma membrane; CAD also signals (directly or indirectly) to nuclear receptors (NHRs) to activate cyp‑35b, cror‑1 and pgp‑13, forming a feedback loop.
@plosbiology.orgSep 24, 2026, 12:55 PM

Cationic amphiphilic drugs (CADs) can disrupt lysosomal function. Peter Roy &co show that a xenobiotic module couples CYP-35B–mediated CAD catabolism to efflux in #Celegans, possibly to #detoxify natural products generated by microbes in the soil 🧪 buff.ly/4BFpg7V

Working model of the CAD Defense Pathway. CAD metabolites and polar lipids are exported by PGP‑13 and PGP‑14 across the plasma membrane; CAD also signals (directly or indirectly) to nuclear receptors (NHRs) to activate cyp‑35b, cror‑1 and pgp‑13, forming a feedback loop.
@plosbiology.orgSep 23, 2026, 8:00 AM

Cationic amphiphilic drugs (CADs) can disrupt lysosomal function. Peter Roy &co show that a xenobiotic module couples CYP-35B–mediated CAD catabolism to efflux in #Celegans, possibly to #detoxify natural products generated by microbes in the soil 🧪 buff.ly/4BFpg7V

Working model of the CAD Defense Pathway. CAD metabolites and polar lipids are exported by PGP‑13 and PGP‑14 across the plasma membrane; CAD also signals (directly or indirectly) to nuclear receptors (NHRs) to activate cyp‑35b, cror‑1 and pgp‑13, forming a feedback loop.
@vashiva.bsky.socialSep 16, 2026, 6:59 PM

Your body has a natural detoxification process. Learn the framework that personalizes your journey back to homeostasis.

#Systems #Health #PersonalizedHealth #Wellness #Detoxify

Sep 16, 7 PM. RSVP 👇

systemshealth.com/tutorial/?ut...