Recent research from Dr. Jessica Rosin’s lab at @dmcbrainhealth.bsky.social uncovered how colony-stimulating factor 1 receptor (#CSF1R)-expressing immune cells help guide the formation of bones, teeth, and facial structures during #EmbryonicDevelopment.

🧫 https://bit.ly/3T9CPbm

Notably, #CSF1 levels across tissues closely correlated with macrophage numbers. Blocking #CSF1 strongly depleted macrophages across cardiac and skeletal muscles, whereas loss of IL-34, the alternative #CSF1R ligand, had no effect.

Finally, we asked: what mediates this coupling between mitochondrial activity and macrophage❓ scRNA-seq across muscles with different metabolic states pointed to #CSF1 - #CSF1R signaling—a key pathway controlling macrophage survival and proliferation.