#Bcl2 family proteins regulate cell survival and death, with roles spanning autophagy, calcium #homeostasis, and mitochondrial dynamics, offering therapeutic promise through BH3 mimetics. #medsky

To read: doi.org/10.1007/s115...

#currentmedicalscience #CellBiology

Integrating single-cell imaging, multi-omics analyses, mechanistic studies, therapeutic modeling & a Phase Ib trial, our study identifies BCL-2 as a therapeutic vulnerability across heterogeneous CRPC.

Congrats to Anmbreen Jamroze, Dean G. Tang, Gurkamal Chatta & our team!
#ProstateCancer #BCL2