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@sigtrans-sttt.bsky.socialOct 3, 2026, 4:30 PM

Modulating #BACE1 transcription offers a different route to targeting #Amyloid pathology. Chlorhexidine suppresses BACE1 via a SOCS3-dependent JAK/STAT response, reducing amyloid pathology and cognitive deficits in AD models.

#STTT #OpenAccess: doi.org/10.1038/s413...
#CellTherapy

Transcriptional modulation of β-Secretase ameliorates amyloid pathology and cognitive deficits in Alzheimer’s disease models
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