@genesndiseases.bsky.socialCould #ferroptosis overcome treatment resistance in #ProstateCancer?
This review highlights key regulatory pathways, biomarkers and combination strategies with anti-androgen therapy, chemotherapy and #immunotherapy.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...
@elementjournal.bsky.socialš¢ Join us Oct 21 at Zhejiang University!
Prof. Tom Vanden Berghe, Executive Editor of Element (University of Antwerp), will speak on āTargeting Ferroptosis in Disease.ā
š Oct 21 | 14:00ā17:00 (UTC+8)
š Online Zoom Meeting Register: oaemesas.feishu.cn/share/base/f...
@fudiwang.bsky.socialProf Raphaƫl Rodriguez (Institut Curie) gave a fantastic lecture yesterday afternoon (Oct 14) at Zhejiang University, Hangzhou, China. We enjoyed stimulating, in-depth discussions. Such a rewarding experience. #ferroptosis #Ironmetabolism @elementjournal.bsky.social @fudiwang.bsky.social
@fudiwang.bsky.socialWe are honored to host Prof Tom Vanden Berghe (University of Antwerp) for our Breakthrough Summit & Element Distinguished Lecture, 14:00ā17:00, Oct 21 at Zhejiang University. His keynote: To Die or Not to Die: Targeting Ferroptosis in Disease. #Ferroptosis #ironmetabolism @elementjournal.bsky.social
@medchemexpress.bsky.socialš #Ferroptosis Reaches the Clinic: A Phase I trial evaluated CNSI-Fe in 19 patients with refractory solid tumors.
ā¢ 84.2% DCR in injected lesions
ā¢ 10.5% ORR in injected lesions
ā¢ 5.3% overall ORR
š§Ŗ Explore MCEās products and 1,276-compound Ferroptosis Compound Library: https://ow.ly/LFZT50ZXVtf
@stephanhacker2.bsky.socialCongratulations to Yilong Zou on being one of the 2026 ICBS Young Chemical Biologist Awardees #ICBS2026.
He gave a great award lecture: "Chemical basis and intervention of ferroptosis in cancer and tissue injury"
@fudiwang.bsky.socialWonderful to welcome our PhD alumni back after two decades. As faculty representative, I shared reflections on life and scholarship at Zhejiang University School of Medicineās 20āyear reunion. #ZhejiangUniversity #bioiron #ferroptosis @elementjournal.bsky.social
@shihcheng.bsky.socialNew study reveals E3 ligase MARCH7 as a critical ferro-guardian, inhibiting ferroptosis by ubiquitylating NCOA4, regulating intracellular FeĀ²āŗ homeostasis. #Ferroptosis PMID:42049018, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00388-0 #Medsky #Pharmsky #RNA #ASHG #ESHG š§Ŗ
@genesndiseases.bsky.socialMetastatic #PancreaticCancer remains difficult to treat.
#AI-driven #MultiOmics analysis identifies PSMD10 as a #ferroptosis sensitizer, linking lipid metabolism to tumor vulnerability and revealing a potential therapeutic target.
#GenesAndDiseases: doi.org/10.1016/j.ge...
@commsbio.nature.comTargeting the UCHL5/ALK5 axis reveals a deubiquitination-driven mechanism that promotes autophagy-dependent #ferroptosis in chondrocytes and accelerates #osteoarthritis progression. Read more below!
PDF available: doi.org/10.1038/s420...
@sigtrans-sttt.bsky.socialA phase I trial evaluates CNSI-Fe, a carbon #NanoparticleāFe(II) complex that delivers Fe iron directly into tumors to trigger #Cancer cell #Ferroptosis, showing a favorable safety profile and preliminary antitumor activity.
@sigtrans-sttt.bsky.socialHow do #Cuproptosis and #Ferroptosis intersect across disease?
This review connects metal metabolism, redox imbalance, organelle crosstalk, and regulatory networks with therapeutic strategies, #Biomarkers, and patient stratification.
#STTT #OpenAccess: doi.org/10.1038/s413...
#PrecisionOncology
@fudiwang.bsky.socialOur Science Bulletin @sciencebulletin.bsky.social cover art and animation draw inspiration from Three Pools Mirroring the Moon. Either loss or excess of SLC7A11 disrupts amino acid homeostasis and induces ferroptosis, promoting MASLD. PMID: 39366830 #Ferroptosis #CellDeath #MASLD #MAFLD
@fudiwang.bsky.socialHappy Mid-Autumn Festival. Under the full moon, we pursue truth and harvest discovery. May wisdom and abundance abide with you.#Ironmetabolism #Ferroptosis @nature.com @cellpress.bsky.social @science.org @elementjournal.bsky.social @brentstockwell.bsky.social @linkermannlab.bsky.social
@genesndiseases.bsky.social#InflammatoryBowelDisease (IBD) involves more than persistent inflammation.
This review highlights how #ferroptosis, iron overload and microbiotaāimmune interactions drive barrier damage and reveal new therapeutic targets.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...
@genesndiseases.bsky.socialHow does #ferroptosis drive cardiovascular, kidney and metabolic disorders?
This review highlights iron dysregulation, GPX4 inactivation and #LipidPeroxidation as key mechanisms and potential therapeutic targets in CKMS.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...
@elementjournal.bsky.socialElement Scientific Exploration Webinar
š Oct 21, 2026 | 13:30 (UTC+8)
š Zhejiang University + Online
Join Prof. Tom Vanden Berghe for āTo Die or Not to Die: Targeting Ferroptosis in Diseaseā
Scan the Poster to Register Free
#Ferroptosis #CellDeath @fudiwang.bsky.social
@genesndiseases.bsky.socialControlling #ferroptosis may help limit #BrainInjury after #IntracerebralHemorrhage.
This study shows MEF2C suppresses oxidative stress and FeĀ²āŗ overload by activating FGF21, revealing a potential therapeutic pathway.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...
@mitoworld.bsky.socialHappy #Mitochondria Monday ;) Kick off your week with Christian Frezza's @biomednews.bsky.social curation on #mitochondriametabolism #mitocancer and #ferroptosis advances:
@fudiwang.bsky.socialOur new review has just been published in Nature Reviews Nephrology @natrevneph.nature.com . This review centers on ferroptosisādriven renal injury across multiple kidney diseases.š Free to read full text: rdcu.be/hu1mDMxZvvXa
#ferroptosis #KidneyDiseases #nature #nutrition
