@jem.orgBiallelic loss-of-function PTPN6 variants lead to inflammatory lung disease and hemolytic #anemia. New report from S. Farshid Moussavi-Harami, Marco Tartaglia, Clifford A. Lowell, Mark R. Looney, Alice Y. Chan (UCSF) and colleagues:
rupress.org/jem/article/...
@discovimmunol.bsky.socialAbatacept suppresses T cell activation, but how durable is its effect?
Research shows its inhibitory impact is short-lived in vivo, diminishing significantly once treatment stops 🧬
@mohameddiab.bsky.socialATP is not always pro-inflammatory: rethinking purinergic signalling in cancer and autoimmunity
Doi: dx.doi.org/10.1002/ardp...
#Springer_Nature
#Purinergic_Signalling
#ATP_Dogma #P2X7 #eATP #Treg #Biochemistry #Autoimmunity #Good_Health #SDG_3
@coltonconsortium.bsky.socialWe’re excited to welcome Jonathan Miner, MD, PhD of @pennmedicine.bsky.social to our Virtual Speaker Series! His talk: “Proteolysis-targeting Chimeras for the Treatment of Autoimmune Diseases.” Free for the #autoimmunity & #immunology communities.
🗓️ Oct. 20, 11 a.m. ET
Register: bit.ly/3WpB3np
@i3h-upenn.bsky.socialTune in next Tuesday! Jonathan Miner, MD, PhD (@pennmedicine.bsky.social) is the next speaker in the @coltonconsortium.bsky.social Virtual Speaker Series. Free and open to the #autoimmunity and #immunology research communities.
🗓️ Oct. 20, 11 a.m. ET
Register: https://bit.ly/3WpB3np
@discovimmunol.bsky.socialPathogenic CD4⁺ T cells in experimental uveitis share key features with those seen across immune-mediated inflammatory diseases, highlighting common pathways driving chronic inflammation 🧬
@achronicvoice.com"Because #helminths need to remain in the host to survive, they have found a way to dial down this #inflammatory, #parasite -fighting response and shift the host into a more regulatory state.": buff.ly/C283uzO
via YaleMed
#autoimmunity #rheumatology #MedSky #parasitic #immunology #ImmuneSystem
@castltrastondrs.medsky.networkchronic T cell receptor (TCR) signalling, together with sustained LAG3 signalling and other inhibitory receptor signalling, drives T cell dysfunction, highlighting LAG3 as a promising therapeutic targeted immunotherapy in oncology and #autoimmunity
PDF www.nature.com/articles/s41...
@jem.orgHelios is critical for Treg effector differentiation in #adipose #autoimmunity. New study from Angela M. Thornton, Ethan M. Shevach and colleagues @niaidnews.bsky.social:
rupress.org/jem/article/...
@rupress.orgIn @jem.org, Moussavi-Harami, Tartaglia, Lowell, Chan et al. report that biallelic loss-of-function variants in PTPN6, encoding the immune-regulatory phosphatase SHP1, cause #anemia & fatal lung #hyperinflammation in families from diverse ethnic backgrounds rupress.org/jem/article/...
#Autoimmunity
@jem.orgMoussavi-Harami, Tartaglia, Lowell, Chan et al. report that biallelic loss-of-function variants in PTPN6, encoding the immune-regulatory phosphatase SHP1, cause #anemia and fatal lung #hyperinflammation in families from diverse ethnic backgrounds. rupress.org/jem/article/...
@newsen.bsky.socialWerfen Unveils QUANTA Link® 5.0: Transforming Autoimmune Lab Operations with a Web-Based Platform #United_States #San_Diego #Werfen #Autoimmunity #QUANTA_Link
@rupress.orgIn @jem.org, Thornton et al. demonstrate that in #Tregs, the transcription factor Helios directly controls Tcf1, Lef1, Id3, and Bach2 to regulate effector Treg generation and terminal differentiation. Mice with Helios-deficient Tregs show #adipose -specific #autoimmunity. rupress.org/jem/article/...
@jem.orgThornton, Shevach et al. demonstrate that in #Tregs, the transcription factor Helios directly controls Tcf1, Lef1, Id3, and Bach2 to regulate effector Treg generation and terminal differentiation. Mice with Helios-deficient Tregs show #adipose -specific #autoimmunity. rupress.org/jem/article/...
@genesndiseases.bsky.socialUNC93B1 influences #autoimmunity beyond TLR trafficking.
A gain-of-function variant linked to early-onset #lupus enhances dendritic-cell activation and #AntigenPresentation, promoting T-cell differentiation and immune dysregulation.
#GenesAndDiseases: doi.org/10.1016/j.ge...
@researchdent-tums.bsky.socialCan low saliva flow indicate more than just autoantibodies in oral lichen planus? A study finds reduced saliva but no increase in anti-M3R autoantibodies in OLP patients. #OralHealth #Autoimmunity
www.rimpacts.com/rd/p?c=10058... 📄DOI: doi.org/10.1002/hsr2...
@jhumimmunity.orgHigh prevalence of #autoantibodies neutralizing type I IFNs in Japanese patients with #hepatitis C. New study from Maki Taniguchi, Satoshi Okada and colleagues (Hiroshima University):
rupress.org/jhi/article/...
@ceijournal.bsky.socialA simpler, highly specific way to detect AIH? This study shows that MF-SMA patterns on vascular smooth muscle cells are easy to recognize and match gold-standard specificity, offering a more reliable diagnostic approach. 🧬
@thelancetendo.bsky.socialPublished in The Lancet Regional Health – Southeast Asia
#Iodine nutrition, #thyroid function, & thyroid #autoimmunity four decades after Universal Salt Iodisation in India: a cross-sectional study among schoolchildren (ICMR-SALT-T 1) www.thelancet.com/journals/lan...
#OpenAccess
@stillrollingoutdoors.comNearly ten years of searching for the help I wasn't getting.
Not healed. Not in remission. No miracle narrative.
Just a steadier floor under shaky legs.