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@thelancetendo.bsky.social Sep 29, 2026, 9:45 AM

Also read the original TimeCapsule article:
A quarter-century of progress: innovations in lipid medicine that transformed cardiovascular prevention thelancet.com/journals/lan...
#LDL #cholesterol #ASCVD #statins #PCSK9 inhibitors

#MedSky #EndoSky #CardioSky

@thelancetendo.bsky.social Sep 29, 2026, 9:45 AM

25 Years of Lipid Medicine youtube.com/watch?v=atCH...
#LDL #cholesterol #ASCVD
#statins #PCSK9 inhibitors

#MedSky #EndoSky #CardioSky

@thelancetendo.bsky.social Sep 28, 2026, 2:16 PM

#Semaglutide was effective in decreasing #CKD progression regardless of the administration route or indication (type 2 #diabetes or #obesity), adding to the evidence provided by FLOW in people with type 2 diabetes & CKD www.thelancet.com/journals/lan...
#T2D

#MedSky #EndoSky #RenalSky #CardioSky

@thelancetendo.bsky.social Sep 28, 2026, 8:42 AM

Published in @ebiomedicine.bsky.social

Metabolomic profiling of ultra-processed food consumption and #cardiovascular risk in Spanish preschool children: a cross-sectional study www.thelancet.com/journals/ebi...
#UPFs #CVD
#OpenAccess

#MedSky #EndoSky #CardioSky

@thelancetendo.bsky.social Sep 28, 2026, 8:40 AM

Published in @lancetrh-europe.bsky.social

Prenatal high-dose vitamin D supplementation and offspring bone mineral content and density at age 13 years: a secondary analysis of a randomised clinical trial www.thelancet.com/journals/lan...
#VitaminD #BoneHealth
#OpenAccess

#MedSky #EndoSky

@thelancetendo.bsky.social Sep 28, 2026, 8:37 AM

Published in @eclinicalmed.bsky.social

Overnight metyrapone in mild autonomous cortisol secretion: a single-centre, single-arm, phase 2 trial www.thelancet.com/journals/ecl...
#OpenAccess

#MedSky #EndoSky

@springermedicine.com Sep 26, 2026, 10:54 AM

Examine the pathophysiology, clinical presentation, diagnostic approach, and neuroimaging features for infiltrative and inflammatory disorders involving the pituitary gland, with strategies to aid recognition and management.

👉️ buff.ly/Ql9BBHL

#EndoSky

@thelancetendo.bsky.social Sep 26, 2026, 8:26 AM

New—New genomic understanding and challenges in clinical care of #Turner syndrome thelancet.com/journals/lan...
#short stature #hypergonadotropic #hypogonadism delayed #puberty #ovarian dysgenesis #infertility #neurocognitive challenges #congenital #heart disease #endocrine disorders

(A) All-cause mortality is increased in Turner syndrome, with considerable differences between karyotypes (based on data from Viuff and colleagues). (B) Cause-specific excess mortality is raised for several disease groups, with circulatory disease being the largest contributor (based on data from Schoemaker and colleagues).

@thelancetendo.bsky.social Sep 24, 2026, 1:17 PM

Early findings support the feasibility of generating functional #parathyroid-like cells through biologically informed programming, with in-vitro and in-vivo validation studies underway www.thelancet.com/journals/lan...
#hypoparathyroidism #stemcells #PTH

#MedSky #EndoSky

Staged differentiation protocol directs human pluripotent stem cells through the definitive endoderm, anterior foregut endoderm, and pharyngeal endoderm towards a parathyroid-like identity. Gene expression analyses demonstrate induction of parathyroid-associated markers, including GCM2 and PTH, over a 36-day differentiation period. PTH=parathyroid hormone. PAX1=paired box 1. PAX9=paired box 9. GCM2=glial cells missing 2.

@thelancetendo.bsky.social Sep 24, 2026, 7:48 AM

Marcel H A Muskiet & colleagues comment on:
The #glucagon renaissance in #obesity therapeutics www.thelancet.com/journals/lan...

#MedSky #EndoSky

@thelancetendo.bsky.social Sep 23, 2026, 9:25 AM

Published in @eclinicalmed.bsky.social

The effect of #SGLT2 inhibitors, #GLP-1 receptor agonists, or #DPP-4 inhibitors on #stroke risk in type 2 #diabetes: a nationwide longitudinal cohort study in Sweden with contextualisation analysis www.thelancet.com/journals/ecl...
#T2D
#OpenAccess
#EndoSky

@thelancetendo.bsky.social Sep 23, 2026, 8:35 AM

#Cholesterol-lowering medicine has changed almost beyond recognition over the past 25 years — from early #statin trials to today's longer-acting, less frequently dosed therapies, some of which may eventually require only one or two doses a year www.youtube.com/watch?v=atCH...
#LDL #ASCVD

#EndoSky

@thelancetendo.bsky.social Sep 21, 2026, 5:18 PM

All patients with #Addison's disease should be given a #steroid emergency card and provided with and trained to use a glucocorticoid injection kit www.thelancet.com/journals/lan...
primary #adrenal insufficiency

#MedSky #EndoSky

(A) National Health Service Steroid emergency card (UK). (B) European Society of Endocrinology bilingual steroid emergency card with German translation and QR code. In North America, a medical alert bracelet or necklace is used.

@thelancetendo.bsky.social Sep 21, 2026, 4:44 PM

#Obesity is increasingly managed with medications as #disease-modifying therapies, reflecting its role as a gateway disease driving metabolic, cardiovascular, reproductive, neuropsychiatric, and mechanical conditions www.thelancet.com/journals/lan...

#MedSky #EndoSky

Colour coding reflects the overall direction of available evidence and does not account for heterogeneity between trials or differences in effect size. Green dot: currently available trials indicate exclusively or predominantly beneficial effects. Yellow dot: currently available trials indicate varying effects (or results are interpretable in varying ways), where evidence does altogether not indicate clear beneficial or clear adverse effects. Red dot: currently available trials indicate exclusively or predominantly adverse effects. Grey dot: currently available trials have not detected an effect on the outcome. White dot: unknown, currently no trials available.

@thelancetendo.bsky.social Sep 21, 2026, 4:38 PM

Published in @lancetgh.bsky.social

Global inequalities in #cardiometabolic care and achievable #cardiovascular risk reduction by wealth, region, and sex: a pooled analysis of individual participant data from 76 countries www.thelancet.com/journals/lan...
##OpenAccess

#MedSky #EndoSky #CardioSky

@thelancetendo.bsky.social Sep 21, 2026, 12:49 PM

#Intermittent #fasting, the practice of periodically fasting for up to 48 h, has surged in popularity over the past decade. An estimated 13% of adults in the USA practice intermittent fasting, making it the third most commonly practiced diet www.thelancet.com/journals/lan...
#T2D

#MedSky #EndoSky

@thelancetendo.bsky.social Sep 20, 2026, 4:00 PM

On average, four in five adults with #diabetes experience diabetes #stigma & one in five experience discrimination (ie, unfair & prejudicial treatment) due to diabetes, such as in health care, education, & employment www.thelancet.com/journals/lan...
#FREE to read w/reg (also FREE)

#MedSky #EndoSky

@thelancetendo.bsky.social Sep 20, 2026, 3:18 PM

Several studies have shown that short-term exposure (days) to #air #pollution is associated with #insulin #resistance, a primary predisposing condition to type 2 #diabetes across various concentrations and age groups www.thelancet.com/journals/lan...
#T2D #airpollution

#MedSky #EndoSky #CardioSky

ACTH=adrenocorticotropic hormone. AMP=activated molecular patterns. CRH=corticotropin releasing hormone. DAMPs=disease-activated molecular patterns. FA=fatty acids. HETES=hydroxyeicosatetraenoic acids. HODES=hydroxyoctadecadienoates. IFN=interferon. IκB=IκB kinase. MyD88=myeloid differentiation primary response protein 88. NADPH=nicotinamide adenine dinucleotide phosphate. NF-κB=nuclear factor κB. oxPAPC=oxidised phospholipid 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine. PAMPs=pathogen. PRRs=pattern recognition receptors. RNS=reactive nitrogen species. ROS=reactive oxygen species. TfR=transferrin receptor. TLR=toll-like receptors.

@thelancetendo.bsky.social Sep 20, 2026, 3:12 PM

Also check out the Video Abstract:
25 Years of Lipid Medicine youtube.com/watch?v=atCH...
#LDL #cholesterol #ASCVD

#MedSky #EndoSky #CardioSky

@thelancetendo.bsky.social Sep 20, 2026, 3:10 PM

Artificial intelligence (#AI) use in #diabetes care is increasingly being explored to personalise care for people with diabetes and adapt treatments for complex presentations www.thelancet.com/journals/lan...
#T1D #T2D

#MedSky #EndoSky