Cryoprotectants-assisted plunge freezing of thick brain tissue specimens for targeted physiologically relevant cryo-imaging in situ pubmed.ncbi.nlm.nih.gov/42716017/ #cryoEM

💡 The idea is simple: getting to know your data is often the shortcut to more efficient particle picking. In our latest #CryoSPARC blog post, we cover how to speed up #cryoEM data processing through efficient early curation of your dataset. 👉 cryosparc.com/blog/curatio...

Sequential assembly in vivo of the bacteriophage P22 genome translocation channel www.biorxiv.org/content/10.64898/2026.09.03.749273v1 #cryoEM

Cryo-EM structure of detergent-bound Vibrio cholerae MakA captures a candidate intermediate between the soluble form and mature assembly of an α-pore-forming toxin www.biorxiv.org/content/10.64898/2026.09.08.748681v1 #cryoEM

📰Happy to share our preprint.🥳Here we investigate🔬, the essential role of the conserved RNA helicase Drs1. We show that its engagement and activity license timely incorporation of 25S rRNA domain III into maturing nucleolar pre-60S subunits.👇
doi.org/10.64898/2026.09.05.749353
#cryoEM #ribosome #RNA

RNA helicase Drs1 gates 25S rRNA domain III incorporation during early nucleolar pre-60S maturation www.biorxiv.org/content/10.64898/2026.09.05.749353v1 #cryoEM

Wet-dry cycle-mediated micelle-to-vesicle transition in sodium dodecylbenzenesulfonate solutions pubmed.ncbi.nlm.nih.gov/42707596/ #cryoEM

Structural insights into RNA phosphorylation by the RNase PNK module of the human rixosome complex pubmed.ncbi.nlm.nih.gov/42708412/ #cryoEM

Membrane Curvature Generation by the Caveolin 8S Complex and the Role of Cholesterol pubmed.ncbi.nlm.nih.gov/42708673/ #cryoEM

Structure-based design of soluble prefusion-stabilized herpes simplex virus type 2 glycoprotein B antigens pubmed.ncbi.nlm.nih.gov/42709545/ #cryoEM

Cryo-EM structure of TGFBIp fibrils driven by a corneal dystrophy-linked mutation enables design of peptide inhibitors of aggregation pubmed.ncbi.nlm.nih.gov/42709813/ #cryoEM

The native structure of the Trichonympha centriole cartwheel reveals a zigzag stacking pattern pubmed.ncbi.nlm.nih.gov/42709820/ #cryoEM

Structural basis of a SWI/SNF-associated transcription pre-initiation complex pubmed.ncbi.nlm.nih.gov/42710485/ #cryoEM

Fantastic milestone. Congratulations to the Utrecht and NeCEN teams! Exciting to see the Krios 5 already delivering, and looking forward to many more great #cryoEM results ahead.

Structural insights into actin severing and capping by gelsolin pubmed.ncbi.nlm.nih.gov/42710486/ #cryoEM

Multiscale Modeling Primer: Focus on Chromatin and Epigenetics pubmed.ncbi.nlm.nih.gov/42710675/ #cryoEM

Cryo-EM structure-based discovery of etravirine as a specific inhibitor of PRMT5/pICln protein-protein interaction for prostate cancer treatment pubmed.ncbi.nlm.nih.gov/42710907/ #cryoEM

Transition Intermediates Encode Ligand Efficacy at the μ-Opioid Receptor-Gi Protein Complex www.biorxiv.org/content/10.64898/2026.09.02.748988v1 #cryoEM

Our first #cryoEM map from the Krios 5 recently installed at Utrecht University as part of the EMPower-funded upgrades to NeCEN. Hopefully the first of many more!

Structural insights into MBOAT2 catalysis, product retention, and ligand exchange www.biorxiv.org/content/10.64898/2026.09.05.749645v1 #cryoEM